Oxime antidotes for reactivation of cholinesterases inhibited by highly poisonous organophosphates (REACT)

Název projektu anglicky
Oxime antidotes for reactivation of cholinesterases inhibited by highly poisonous organophosphates (REACT)
Anotace anglicky
The highly toxic organophosphorus compounds were used during serious incidents in the last decade. These agents are causing life endangering intoxication that are usually treated by combination of antidotes, where only reactivators (oximes) are able to split organophosphates from cholinesterase active site and restore their physiologic activity. However, the standard oximes were found ineffective antidotes for such highly toxic organophosphorus compounds. For these reasons, the current research is based on searching for oximes with increased reactivation for the specific organophosphates. Thus, this project is focused on proof of concept of increased organophosphate reactivation and organism protection using double charged pyridinium oximes, which will be designed, prepared and thoroughly evaluated for these purposes.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
30107 - Medicinal chemistry
OECD FORD - vedlejší obor
30108 - Toxicology
OECD FORD - další vedlejší obor
30104 - Pharmacology and pharmacy
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
FP - Ostatní lékařské obory<br>FR - Farmakologie a lékárnická chemie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GF-R
Datum dodání záznamu
23. 5. 2026

Podobné projekty(10)