Je AHK4/CRE1 z Arabidopsis thaliana falešným "decoy" receptorem?

Název projektu anglicky
Is Arabidopsis AHK4/CRE1 decoy receptor?
Anotace anglicky
Due to their sessile nature, plants evolved mechanisms to integrate environmental cues into endogenous developmental programs. Phytohormones act as integrators in fine-tuning growth and development and their activities are under stringent control of multiple positive- and negative- feedback mechanisms. Here we propose novel mechanism of attenuating cytokinin signalling. We intend to show that Arabidopsis cytokinin receptor AHK4/CRE1 acts as so-called “decoy receptor”. Our findings suggest that the change in alternative splicing fidelity of CRE1 transcripts is triggered by active cytokinin that results in accumulation of CRE1 transcripts retaining particular intron. Intron retention causes introduction of premature termination codon and, when examined in heterologous system, its translated molecules appear to retain physiologically significant ligand binding affinity but are unable to transduce signal due to its truncated nature. Once intron-retained transcripts are translated, they are likely to compete with endogenous cytokinin receptors and thus attenuate signalling of its own.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10611 - Plant sciences, botany
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EF - Botanika

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP22-GA0-GJ-R
Datum dodání záznamu
21. 2. 2022

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