Funkční studie mikroRNA u nerálních kmenových buněk v průběhu diferenciace

Název projektu anglicky
Functional studies of miRNAs and protein-coding genes involved in stem cell-specification during neural development.
Anotace anglicky
During the past decade, small non-coding RNAs (miRNAs) were identified as crucial post-transcriptional regulators of gene expression. They were also directly linked with human embryonic stem cell (hESC) physiology and maintenance of key stem cell properties: self-renewal and pluripotency. Importantly, their expression is directly regulated by key stem cell transcription factors – Oct4, Nanog, and Sox2. These pathways are therefore being extensively studied in undifferentiated hECS, however which molecular mechanisms are employed during the onset of differentiation of hESCs is less well described. Therefore, we aim to study how specific miRNAs and protein-coding genes function together to maintain NSC-specific properties - i.e. the ability to self-renew and to differentiate. And since deregulation of these processes is a hallmark of cancer and/or neural degeneration, we believe that studying cell-specific transcription factors and/or miRNAs in these two processes will contribute to the gain of knowledge with potential relevance to patients’ treatment in the future.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10601 - Cell biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP22-GA0-GJ-R
Datum dodání záznamu
21. 2. 2022

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