Role proteáz FtsH v biogenezi tylakoidních membrán a fotosyntetických komplexů v sinicích

Název projektu anglicky
The role of FtsH proteases in biogenesis of thylakoid membranes and photosynthetic complexes in cyanobacteria
Anotace anglicky
FtsHs are universally conserved transmembrane metalloproteases. In plants, they are key players in ongoing photosynthesis and an early stage of plastid development. In cyanobacteria, FtsHs are mostly known for PSII repair during photoinhibition. Our preliminary results, however, indicate that cyanobacterial FtsHs are also involved in assembly of photosynthetic complexes. They were repeatedly copurified with PSII and PSI reaction centres as well as proteins involved in chlorophyll biosynthesis and thylakoid membrane (TM) formation. Moreover, suppression of the essential FtsH1/3 complex causes aberrant TM architecture. The aim of the project will be specification of the role of FtsHs in PSII and PSI de novo assembly and TM biogenesis. We will focus on FtsHs localization and the effect of FtsH deficiency and overexpression on the photosystem assembly under conditions inducing TM biogenesis. We will also isolate sections of the TM enriched by FtsH complexes and characterize their protein composition. Additionally, we would like to further specify the structure of purified FtsH complexes.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10608 - Biochemistry and molecular biology
OECD FORD - vedlejší obor
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OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CE - Biochemie<br>EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GJ-R
Datum dodání záznamu
26. 6. 2023

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