Vliv estrogenů na epigenom testes/spermií a časný vývoj zárodku

Název projektu anglicky
Effect of Estrogens on Testicular/Sperm Epigenome and Early Embryonic Development
Anotace anglicky
Estrogens are a group of steroid compounds, named for their importance in the estrous cycle. They have been for a long time considered as mainly female hormones, but they also play an important role in regulating male reproductive functions. In our previous studies we described the significant effect of several types of natural and synthetic estrogens on various aspects of sperm and testicular physiology. Despite the large body of evidence about the effect of estrogens on male reproductive functions, the epigenetic effect of estrogens on the process of spermatogenesis and its physiological consequences remains largely unexplored. Therefore, in the proposed project we aim to study the effect of natural and synthetic estrogens on the process of histone-to-protamine transition in testicular tissue, epigenetic profile in testicular cells /sperm and evaluate its heredity and effect on early embryonic development. The expected research outputs of proposed project should bring new important insights into the process of the hormonal regulation of epigenetic functions in males.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10603 - Genetics and heredity (medical genetics to be 3)
OECD FORD - vedlejší obor
—
OECD FORD - další vedlejší obor
—
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP23-GA0-GJ-R
Datum dodání záznamu
26. 6. 2023

Podobné projekty(10)