Role biomolekulárních kondenzátů v diferenciaci zárodečných buněk rostlin

Název projektu anglicky
Biomolecular condensates in plant germline differentiation
Anotace anglicky
Biomolecular condensates are membrane-less compartments that concentrate proteins and nucleic acids via multivalent interactions, and exhibit features of liquid-liquid phase separation. They have been implicated in number of cellular processes and list of their biological functions has rapidly grown over recent years. P-bodies are cytoplasmic condensates involved in translation repression, RNA storage and RNA decay, but how these opposite outcomes are achieved is not resolved. P-bodies are also important for differentiation of plant germline. We showed that P-bodies change composition and functional properties in the course of Arabidopsis meiosis, which represents unique system to study mechanisms of their action and regulation. In this application we propose to combine quantitative imaging and genomic approaches to study the function of P-bodies in plant meiosis. Gained knowledge will fundamentally advance our understanding of gene regulation in plant germline, and proposed technological developments will contribute to research on biomolecular condensates in plants.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10601 - Cell biology
OECD FORD - vedlejší obor
10604 - Reproductive biology (medical aspects to be 3)
OECD FORD - další vedlejší obor
10611 - Plant sciences, botany
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
EA - Morfologické obory a cytologie<br>EB - Genetika a molekulární biologie<br>EF - Botanika

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-GA0-GX-R
Datum dodání záznamu
21. 2. 2025

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