Illuminating the deep evolutionary roots of the Ras superfamily of GTPases

Název projektu anglicky
Illuminating the deep evolutionary roots of the Ras superfamily of GTPases
Anotace anglicky
Diversification of cellular structures and functions is underlined by evolution of proteins, with GTPases of the Ras superfamily being particularly relevant for the origin of cellular complexity and its variation across the eukaryote phylogeny. Recent research, including my own contribution, have pointed to the surprisingly deep evolutionary roots of the eukaryotic GTPase diversity, predicting a complex complement in the last eukaryotic common ancestor and its derivation from GTPases in the recently discovered Asgardarchaeota. These advances, however, left open a number of questions and defined new ones, some of which I want to address. Together with a PhD student we will reconstruct the diversity and evolution of the Ras family at the paneukaryotic scale, will investigate novel GTPases putatively associated with the cilium, will try to obtain the first functional data about a previously uncharacterized ancient GTPase, and will dig deeper into the diversity of the Ras superfamily in asgardarchaeotes. We will thus substantially improve our knowledge of the early GTPase evolution.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10608 - Biochemistry and molecular biology
OECD FORD - vedlejší obor
10601 - Cell biology
OECD FORD - další vedlejší obor
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
CE - Biochemie<br>EA - Morfologické obory a cytologie<br>EB - Genetika a molekulární biologie

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP26-GA0-GY-R
Datum dodání záznamu
12. 5. 2026

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