Peptidy kontrolující membránové zakřivení

Název projektu anglicky
Peptides controlling membrane curvature
Anotace anglicky
The project focuses on lipid membrane curvature and peptides that are sensitive to curvature or capable of modulating curvature. Membrane curvature plays a crucial role in many physiological cellular processes, such as endocytosis, exocytosis, vesicle transport, and cell signaling. Modulation of membrane curvature is also associated with pathological phenomena of viral infection, such as membrane fusion and vesicle budding. The main aim of this project is the creation of a peptide library capable of detecting various types of membrane curvature, ranging from negative to positive and various Gaussian curvatures. We will use this library to develop a tool for evaluating the sensitivity to membrane curvature in protein segments, which are involved in selective protein sorting. We will validate the tool on mutants and chimeric variants of G protein-coupled receptors (GPCRs) that should exhibit preferences for different curvatures and may thus influence cellular signaling. The insights gained could also be applied to the development of peptides that detect and inhibit membrane fusion, thereby interfering with the life cycle of enveloped viruses. This project will not only contribute to fundamental research in membrane biophysics but also pave the way for new opportunities in biotechnology and the development of therapeutic tools.

Kategorie VaV
ZV - Základní výzkum
OECD FORD - hlavní obor
10610 - Biophysics
OECD FORD - vedlejší obor
10610 - Biophysics
OECD FORD - další vedlejší obor
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CEP - odpovídající obory <br>(dle <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">převodníku</a>)
BO - Biofyzika

Důvěrnost údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Systémové označení dodávky dat
CEP25-MSM-LU-R
Datum dodání záznamu
18. 9. 2025

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