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2 747 (0,085s) •

Projekt

Search for novel nucleoside analogs as antivirals against medically important flaviviruses. (LTAUSA18016)

the antiviral activity and cytotoxicity of the synthesized compounds in vitro using the antiviral effect of the nucleosides with a strong in vitro anti-flavivirus activity of selected flaviviruses and describe the signature mutatio...

Microbiology

  • 2019 - 2022
    • •
  • 12 123 tis. Kč
    • •
  • 11 329 tis. Kč
    • •
  • MŠMT
Projekt

Utilisation of genetical analysis to the diagnostics of human cytomegalovirus infection in immunodeficient patients (NR9418)

of the infections. B) Setting of the methods for detection of antivirals resistence-associated for characterisation of CMV strains obtained from patients with poor response to antiviral therapy.......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2007 - 2009
    • •
  • 2 867 tis. Kč
    • •
  • 2 599 tis. Kč
    • •
  • MZ
Projekt

TARGETING HIV INTEGRATION CO-FACTORS, TARGETING CELLULAR PROTEINS DURING NUCLEAR IMPORT OR INTEGRATION OF HIV (7E08066)

will find it difficult to develop antiviral resistance against drugs targeting in drug-resistance. Therefore, a continued research effort is required to develop more potent, cheaper and less toxic antivirals. The ...

CE - Biochemie

  • 2008 - 2012
    • •
  • 1 960 tis. Kč
    • •
  • 1 960 tis. Kč
    • •
  • MŠMT
Projekt

Genetic sources of antiviral resistance in the domestic chicken (QL24010315)

The aim of the project is to search for gene variants, ideally short polymorphisms, that predispose the domestic chicken to resilience or complete resistance to viral diseases (especially HPAI, IBV and IBDV). These variants will be sought by...

Husbandry

  • 2024 - 2028
    • •
  • 38 737 tis. Kč
    • •
  • 28 295 tis. Kč
    • •
  • MZe
Projekt

Syntheses of new prodrug forms of biologically active nucleotide analogues (GA14-00522S)

The challenges emerging from the possible resistance and side-effects of marketed antiviral drugs (e.g. nephrotoxicity) are still an impetus for development of new therapeutic agents. In this project, we will focus to several highly...

CC - Organická chemie

  • 2014 - 2016
    • •
  • 4 481 tis. Kč
    • •
  • 4 481 tis. Kč
    • •
  • GA ČR
Projekt

Novel antivirals and antineoplastics (1QS400550501)

The aim of this project is to develop novel antivirals and/or cytostatics based on nucleoside, nucleotide and nucleobase structure, to determine their transport characteristics, metabolism and mechanism of action, under the conditions accept...

CC - Organická chemie

  • 2005 - 2009
    • •
  • 20 500 tis. Kč
    • •
  • 20 500 tis. Kč
    • •
  • AV ČR
Projekt

New Antivirals and Antineoplastics (1M0508)

The aim of the project is to design, synthesize and study novel drug candidates for treatment of viral diseases and neoplasia, compounds active against drug resistent HIV and HBV mutants, poxviruses and RNA viruses.To study new analogs of ac...

CC - Organická chemie

  • 2005 - 2011
    • •
  • 316 074 tis. Kč
    • •
  • 268 113 tis. Kč
    • •
  • MŠMT
Projekt

Study on relationships between toxicity and transport mechanism of antivirals (NT12398)

Antivirals belongs to a relatively new group of drugs with still insufficient at study of transmembrane transport of novel nucleoside antivirals in the kidney of the transport of the antivirals by other compounds potentiall...

FR - Farmakologie a lékárnická chemie

  • 2011 - 2014
    • •
  • 2 822 tis. Kč
    • •
  • 2 822 tis. Kč
    • •
  • MZ
Projekt

Chemical properties of platinum and other metal ion complexes with nucleobases and antiviral nucleotide analogues (OC D8.30)

Synthesis of antiviral compounds with the phosphonate structure containing purine and pyrimidine bases and their aza and deaza analogues, preparation and investigation of their complexes with platinum and other metal ions.......

CC - Organická chemie

  • 1997 - 2001
    • •
  • 2 036 tis. Kč
    • •
  • 1 560 tis. Kč
    • •
  • MŠMT
Projekt

The role of chloroplasts in mechanisms involved in replication and translation of viral-RNA in connection with host resistance (GA522/02/0708)

with susceptibility, tolerance and resistance of host plant and study of role of native inhibitors (coat protein CP, PR-proteins, antiviral factor AVF) of virus multiplication ("systemic acquired resistance"). Therefore we...

ED - Fyziologie

  • 2002 - 2004
    • •
  • 6 030 tis. Kč
    • •
  • 2 025 tis. Kč
    • •
  • GA ČR
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