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1 308 (0,067s) •

Projekt

Modulation of kinases for targeted treatment of haematological and other malignancies (GA23-05474S)

Activities of kinase inhibitors (bioisosteres of olomoucine, bohemine, roscovitine, olomoucine II, etc.) are being studied in our laboratories for a long time and the thousands of analogues already available should substantially help to mee...

Hematology

  • 2023 - 2025
    • •
  • 9 990 tis. Kč
    • •
  • 9 990 tis. Kč
    • •
  • GA ČR
Projekt

Biological activity of synthetic inhibitors of cyclin-dependent kinases (GA204/08/0511)

During our previous projects we have developed several new inhibitors of cyclin-dependent kinases. Most of the described inhibitors showed a preference for CDK1 and CDK2, important regulators of the cell cycle. However, olomoucine II, which is a hydr...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 3 200 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • GA ČR
Projekt

Modulation of CDK and related molecular targets in aggressive non-Hodgkin lymphomas (GA17-14007S)

We have established a massive, unique library of compounds (olomoucine, bohemine, roscovitine, olomoucine II, CAN508, and many others toward cell cycle kinases cdk1, cdk2, cdk5, ERK1) originally created to discover new cytokinins and CDK mod...

FD - Onkologie a hematologie

  • 2017 - 2019
    • •
  • 8 907 tis. Kč
    • •
  • 8 502 tis. Kč
    • •
  • GA ČR
Projekt

Modulation od cyclin-dependent kinases in haematological malignancies (GA14-19590S)

We discovered unusual specificity of cytokinin derivative olomoucine (OC) toward cell cycle kinases (cdk1, cdk2, cdk5, ERK1). This discovery has led to subsequent development of bohemine, roscovitine, olomoucine II, CAN508 and many others. W...

FD - Onkologie a hematologie

  • 2014 - 2016
    • •
  • 8 568 tis. Kč
    • •
  • 8 568 tis. Kč
    • •
  • GA ČR
Projekt

Cytokinin metabolism in tobacco chloroplasts and its regulation (GA206/03/0369)

and roscovitine) as well as of cytoplasmic isoprenoid (lovastatin) or...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 10 732 tis. Kč
    • •
  • 3 170 tis. Kč
    • •
  • GA ČR
Projekt

Modulation of cyclin-dependent kinases for targeted treatment of tumors with molecularly defined deregulation G1/S phase of cell cycle (GA20-25308S)

In this project, we will focus on the development of inhibitors for the targeted treatment of tumors with molecular-defined deregulation of the G1-S phase of the cell cycle (particularly the deregulation of CDK4, D-cyclins and CDKN2A in aggressive ly...

Medicinal chemistry

  • 2020 - 2022
    • •
  • 9 640 tis. Kč
    • •
  • 9 640 tis. Kč
    • •
  • GA ČR
Projekt

Complexes of selected transition metals with cytokinin derivatives synthesis, characterization and biological activity (GA203/04/1168)

, Olomoucine and Roscovitine, i.e previously reported potent cytokinin-derived p34cdc2...

CA - Anorganická chemie

  • 2004 - 2006
    • •
  • 1 587 tis. Kč
    • •
  • 1 587 tis. Kč
    • •
  • GA ČR
Projekt

Targeted Transport of Purine Cyclin-dependent Kinase Inhibitors into Cancer Cells (GA15-15264S)

The project is focused on the synthesis and study of biological effects of some new conjugates of cyclin-dependent kinase inhibitors, derived from cytokinins, which have shown significant anticancer effect, with selected polyamines and folic acid. Th...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
    • •
  • 4 631 tis. Kč
    • •
  • 4 631 tis. Kč
    • •
  • GA ČR
Projekt

Pyrazolo[4,3-d]pyrimidines as a new generation of anticytokinines and inhibitors of cyclin-dependent kinases (KJB4038301)

knowledge (general and our own) of isomeric compounds purines (e.g. roscovitine, which...

CC - Organická chemie

  • 2003 - 2005
    • •
  • 3 654 tis. Kč
    • •
  • 924 tis. Kč
    • •
  • AV ČR
Projekt

Biological activity of new inhibitors of cyclin-dependent kinases (GP204/03/D231)

The discovery of olomoucine as one from the first specific inhibitors of cyclin-dependent kinases (cdk1, cdk2, cdk5) markedly stimulated the development of new generation of antimitotic drugs. Olomoucine and its novel derivatives with increased poten...

CE - Biochemie

  • 2003 - 2006
    • •
  • 1 483 tis. Kč
    • •
  • 583 tis. Kč
    • •
  • GA ČR
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