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4 058 (0,082s) •

Projekt

Analysis of the interactions of mutagens, carcinogens and anti-cancer drugs with biopolymers by means of electrochemical and biochemical methods. (IAA4004901)

of nucleic acids (NA) and proteins (including tumour supressor protein p53) with selected electrodes. 3. Specific interactions of unmodified and modified nucleic acids with proteins (including DNA covalent adduct-specific ...

CE - Biochemie

  • 1999 - 2001
    • •
  • 2 422 tis. Kč
    • •
  • 827 tis. Kč
    • •
  • AV ČR
Projekt

Treating GTD threat using bioactive compounds of botanical origin (8J22FR013)

fungi. Polyphenols can be roughly subdivided into four groups: phenolic acids (derivatives of benzoic acid and cinnamic acid), flavonoids, stilbenes and lignans (Manach on the microbiota dynamics in soil and plants. Theref...

Agricultural biotechnology and food biotechnology

  • 2022 - 2023
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Projekt

Possibilities of electrochemical methods in genomics. Basis for development of DNA sensors. (IBS5004355)

Electroactivity of nucleic acids was discovered by the principal investigator and oriented research to create a solid base for the development of DNA hybridization sensors. Interactions of nucleic acids and model compounds ...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 7 237 tis. Kč
    • •
  • 3 621 tis. Kč
    • •
  • AV ČR
Projekt

Novel electrochemical sensors and sensing techniques for the analysis of nucleic acids structure and interactions (GAP206/11/1638)

for research of biopolymers, including nucleic acids and proteins, as well as bioactive behavior of natural and chemically modified nucleic acids at electrodes surfaces oligonucleotides, interactions of DNA immobilized at ...

CG - Elektrochemie

  • 2011 - 2016
    • •
  • 14 061 tis. Kč
    • •
  • 14 061 tis. Kč
    • •
  • GA ČR
Projekt

Protein-DNA Complexes and Force Field Development (GA20-28231S)

The aim of this proposal is to explore protein-DNA interactions hand in hand with developing force fields (FF) for nucleic acid (NA) simulations. Current NA FFs are known to suffer from intrinsic difficulties in describing non-canon...

Physical chemistry

  • 2020 - 2022
    • •
  • 2 687 tis. Kč
    • •
  • 2 687 tis. Kč
    • •
  • GA ČR
Projekt

Conformational Equilibria in Nucleic Acids and Force Field Development (GA17-16107S)

of nucleic acids. The aim of our proposal is to use molecular dynamics simulations to deepen our understanding of the biologically important equilibria in nucleic acids, such as BI/BII equilibrium of B-DNA, ZI/ZII equilibr...

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2021
    • •
  • 2 563 tis. Kč
    • •
  • 2 485 tis. Kč
    • •
  • GA ČR
Projekt

Analysis of DNA structure and interactions using electrochemical techniques and chemical probes. Novel techniques and sensors for DNA damage detection (GA203/07/1195)

in studies of nucleic acids structure and interactions and/or in detection of DNA the behavior of unmodified and chemically modified nucleic acids, their complexes with low will involve detailed studies of electrochemical ...

CG - Elektrochemie

  • 2007 - 2009
    • •
  • 4 192 tis. Kč
    • •
  • 4 192 tis. Kč
    • •
  • GA ČR
Projekt

Structure and dynamics of DNA nitrogeneous bases, base pairs, oligonucleotides and their complexes with water, ions and drugs (GA203/05/0009)

Structure and dynamics of nucleic acids are determined by molecular interactions and electronic properties of nucleic acid bases. In-depth analysis of the molecular interactions in nucleic acids will be carried out using a ...

CF - Fyzikální chemie a teoretická chemie

  • 2005 - 2007
    • •
  • 4 700 tis. Kč
    • •
  • 4 700 tis. Kč
    • •
  • GA ČR
Projekt

Load of patients treated with hemodialysis by phthalic acid esters (IZ3427)

FM - Hygiena

  • 1996 - 1998
    • •
  • 2 172 tis. Kč
    • •
  • 2 172 tis. Kč
    • •
  • MZ
Projekt

Structure, dynamics and function of DNA (GA203/00/0633)

) simulations of hydrated nucleic acids will be used to study the DNA molecules and functions of nucleic acids (NA) at the atomic level. Wide range of state-of the-art such as interactions of small DNA fragments wi...

CF - Fyzikální chemie a teoretická chemie

  • 2000 - 2002
    • •
  • 2 624 tis. Kč
    • •
  • 1 260 tis. Kč
    • •
  • GA ČR
  • 1 - 10 z 4 058