Filtry
A humanized organoid-based platform for stroke modelling and mRNA-based therapeutic intervention (GA24-11364S)
technologies, disease modeling using brain organoids and mRNA-based therapeutic strategies. The development of new therapeutics is hindered by the incomplete stroke and modulate them by mRNA-based intervention, wi...
Neurosciences (including psychophysiology)
- 2024 - 2026 •
- 10 693 tis. Kč •
- 10 693 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2024 - 31. 12. 2026
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
MicroRNA in central nervous system injury potential roles and therapeutic implications (GA18-21942S)
expression levels by antagonizing mRNA – are dysregulated following different types of CNS injuries. This has got them significant attention as potential therapeutic and mRNAs in the nervous tissue in mice and rat models. ...
Neurosciences (including psychophysiology)
- 2018 - 2021 •
- 8 195 tis. Kč •
- 8 138 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 30. 6. 2021
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Grantová agentura České republiky
Characterization of the ribosome translating pre-spliced mRNAs for the synthesis of antigenic peptide substrates for the MHC-I pathway (GA23-06884S)
that MHC-I APs are produced by a non-canonical mRNA translation event that is distinct data show that translation of pre-spliced mRNAs produces MHC-I AP substrates of mRNA translation, on the source of MHC-I peptides, and ...
Immunology
- 2023 - 2025 •
- 10 603 tis. Kč •
- 10 357 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
Small Compounds Affecting RNA Elements (SCARE) in mRNA 3'UTRs (GA22-20110S)
is non-protein-coding including 3’UTRs of mRNAs with important regulatory functions. This makes them attractive drug targets considering that current therapeutics target only. Therefore, targeting these proteins via their mRNA<...
Biochemistry and molecular biology
- 2022 - 2024 •
- 11 747 tis. Kč •
- 11 456 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
Identification and characterization of a new pathway regulating pre-mRNA splicing (GX23-04754X)
Ability of cell to properly express its genes depends on optimal transcription and splicing. RNA polymerase II transcribes protein-coding genes and produces pre-mRNAs, which co-transcriptionally undergo intron excision by the spliceosome, a ...
Biochemistry and molecular biology
- 2023 - 2027 •
- 49 981 tis. Kč •
- 49 981 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
THE IMPACT OF THERAPEUTIC TARGETING OF BCR SIGNALLING ON GENE EXPRESSION IN B CELL MALIGNANCIES AND ITS PROGNOSTIC AND PREDICTIVE SIGNIFICANCE (NV16-29622A)
-coding genes after therapeutic targeting of BCR (ibrutinib and idelalisib pathways of miRNAs-mRNA affected by BCR inhibition, ii) describe miRNAs that can define potential novel therapeutic approaches that mimic BCR-inhibi...
FD - Onkologie a hematologie
- 2016 - 2019 •
- 9 899 tis. Kč •
- 9 899 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2016 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Transplantation therapy of diabetes with insulin-producing cells derived by reprogramming of non-endocrine pancreatic cells (NV15-25924A)
Transplantation of the whole pancreas or isolated Langerhans islets are currently the only available therapeutic options that allow to cure insulin-dependent reprogramming that is based on the application of synthetic modified mRNA ...
FJ - Chirurgie včetně transplantologie
- 2015 - 2018 •
- 6 146 tis. Kč •
- 6 146 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2015 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Development of an automated universal modular system for the production of biological mRNA vaccines and genetic medecines (EI24_063/0006705)
The project focuses on the development of a prototype of a modular automated universal system for the production of biological mRNA vaccines and genetic therapeutics. It builds upon the successful project “Innovation of Dual Conduct...
Analytical chemistry
- 2025 - 2028 •
- 44 972 tis. Kč •
- 0 tis. Kč •
- MPO
Řešení projektu: 14. 3. 2025 - 30. 6. 2028
Uznané náklady
Podpora ze státního rozpočtu (0%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Regulation of gene expression by a new mRNA-binding factor (GA16-10930S)
Recent studies have shown that more mRNA-binding proteins (mRBP) exist than that one of the tCDK binds mRNA directly in living cells via its conserved region, making it the first mRNA-binding CDK. We hypothesize that the
EB - Genetika a molekulární biologie
- 2016 - 2020 •
- 9 396 tis. Kč •
- 9 396 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 22. 7. 2020
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Mapping mRNP-NUP interactions during nuclear export with a unique mRNA-trap (GC21-19503J)
Eukaryotic mRNAs need to pass through the nuclear pores to reach the cytoplasm. Study of nuclear mRNA export is challenging, because it is fast, and interactions immature mRNAs from starting nuclear export. As a consequence...
Biochemistry and molecular biology
- 2021 - 2023 •
- 6 437 tis. Kč •
- 6 437 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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