Filtry
Modified oligonucleotides derived from 5´-substituted nucleoside 5´-C-phosphonates synthesis and hybridization properties (GP203/04/P273)
Modified oligonucleotides containing the 3´-O-P-CH(R)-5´´ internucleotide linkages derived from 5´-substituted nucleoside 5´-C-phosphonates in the project, and their physico-chemical properties will be studied and the influ...
CC - Organická chemie
- 2004 - 2006 •
- 806 tis. Kč •
- 806 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of STAT 5 protein in cytokine-mediated signaling in normal and malignant human breast epithelium (KJB502070601)
some questions arising from the idea that STAT 5 (signal transducer and activator of transcription 5) may be involved in interferon and estrogen signaling pathways in breast epithelial cells and its functional abnormalities of STAT...
EB - Genetika a molekulární biologie
- 2006 - 2007 •
- 590 tis. Kč •
- 590 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2006 - 1. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
Individual 5-fluorouracil dose individualization in patients with colorectal cancer (NS9693)
The objective of the research is to verify the potential importance of 5-FU pharmacokinetic characteristics and biomarkers reflecting the genetic polymorphism of enzymes involved the efficacy of the drug. The goal is to predict the drug dose...
FR - Farmakologie a lékárnická chemie
- 2008 - 2011 •
- 7 470 tis. Kč •
- 7 257 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Ministerstvo zdravotnictví
New derivatives of 5-azacytosine nucleosides like demethylating therapeutics identification of clinical candidates and efficiency biomarkers. (FR-TI4/625)
The project is focused to the development of new hypomethylating agents based on polymer conjugates of 5-azacytosine nucleosides and their 5,6-dihydro congeners, which will increase plasma half-life of the drug. This will not only pronounce ...
FD - Onkologie a hematologie
- 2012 - 2015 •
- 31 955 tis. Kč •
- 25 152 tis. Kč •
- MPO
Řešení projektu: 1. 1. 2012 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (79%)
Poskytovatel: Ministerstvo průmyslu a obchodu
A novel cariprazine-derived D2/5-HT3 receptor modulators with potential implications for the treatment of schizophrenia and depressive symptoms (GN24-11191O)
, used mainly to alleviate positive symptoms. Due to the high expression of 5-HT3 function, 5-HT3Rs represent a suitable target for influencing the negative and cognitive symptoms of schizophrenia. Thus, 5-HT3R antagonists ...
Pharmacology and pharmacy
- 2024 - 2027 •
- 5 178 tis. Kč •
- 5 178 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2024 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Characterising the regulatory mechanisms at decoy 5’ splice sites (GF24-11219K)
we will focus on decoy 5’ splice sites (d-5’ss), which contain consensus sequences of 5’ splice sites and assemble some spliceosomal components. We will assess the proportion of d-5’ss that assemble non-productive...
Genetics and heredity (medical genetics to be 3)
- 2024 - 2027 •
- 8 364 tis. Kč •
- 8 329 tis. Kč •
- GA ČR
Řešení projektu: 1. 4. 2024 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Analysis of Al sites in the framework of zeolites and catalytic activity of correspondink H+ and Fen+ sites (GP203/08/P593)
The aim of the present project is to develop H-ZSM-5 and Fe-ZSM-5 catalysts of aluminium and silicon will be used for synthesis of ZSM-5 zeolites with Si/Al 40 - 200 spectroscopy will be applied to analyse Al siting in the ...
CF - Fyzikální chemie a teoretická chemie
- 2008 - 2010 •
- 966 tis. Kč •
- 966 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
*Research and development of a new type of injection device with advanced design fulfilling EURO 4 and EURO 5 emission demands. (FF-P2/083)
*A new generation of injection device for C.I. engines fulfilling EURO 4 and EURO 5 emission requirements valid from year 2005 - 2010. Solution is based on new design of injection unit with injection pressure 160 - 200 MPa. Fuel injection is...
JT - Pohon, motory a paliva
- 2003 - 2005 •
- 12 814 tis. Kč •
- 3 962 tis. Kč •
- MPO
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (31%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Intermediates for non-ionic X-ray contrast media - application of principles of Green Chemistry (TA01010606)
The project aim is to develop and validate new technology for production of 5-nitroisophthalic acid, 5-amino-2,4,6-triiodoisophthalic acid and/or for production of other advanced intermediates, which can be used as the X-ray contras...
CC - Organická chemie
- 2011 - 2013 •
- 14 584 tis. Kč •
- 9 460 tis. Kč •
- TA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2013
Uznané náklady
Podpora ze státního rozpočtu (65%)
Poskytovatel: Technologická agentura ČR
The role of DNA methylation and histone modifications in the establishment and maintenance of HIV-1 latency (GP204/08/P616)
for eradication of HIV-1 infection. We found that CpG methylation of the HIV-1 promoter in 5 oftranscriptional silencing. HIV-1 latency related to hypomethylation of the 5?LTR correlates structure of the 5?LTR. In contrast...
EB - Genetika a molekulární biologie
- 2008 - 2010 •
- 1 500 tis. Kč •
- 1 500 tis. Kč •
- GA ČR
Řešení projektu: 3. 3. 2008 - 1. 9. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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