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10 351 (0,097s)

Projekt

Fate decisions in the dental placode an investigation into the signalling factors that determine cell fate decisions in the early oral cavity (GA18-04859S)

Understanding cell fate decisions is an essential goal in developmental biology of disease. In this proposal we aim to investigate the decisions that determine fate of cells during development of odontogen...

Developmental biology

  • 2018 - 2020
  • 8 687 tis. Kč
  • 8 198 tis. Kč
  • GA ČR
Projekt

T cell receptor signaling and fate decisions made by peripheral T cells in homeostasis and during inflammation (GJ16-09208Y)

coreceptor-Lck coupling frequency determines outcomes of cell fate decisions in mature TProper T cell fate choices are required for efficient immune responses as well as for maintaining self-tolerance. In...

EC - Imunologie

  • 2016 - 2018
  • 9 315 tis. Kč
  • 7 968 tis. Kč
  • GA ČR
Projekt

Distribution of biomolecules studied on single cell and subcellular levels in Xenopus early stages to reveal mechanisms of asymmetric cell divisio (GA16-07500S)

elusive. Asymmetry in the cell is induced by polarization of cell fate determinants that become unevenly distributed among progeny cells. Currently, only few determinants of biomolecules expected...

EB - Genetika a molekulární biologie

  • 2016 - 2018
  • 6 273 tis. Kč
  • 6 171 tis. Kč
  • GA ČR
Projekt

The chaperones and stress factors effect on folding and stability of the wild type and mutant cystathionine beta-synthase (CBS) (GP305/02/D167)

The balance between synthesis and degradation determines the steady-state level of given protein in a cell. The fate of the mutant proteins is result of competition try to determine the fate of CBS during ...

EB - Genetika a molekulární biologie

  • 2002 - 2004
  • 580 tis. Kč
  • 580 tis. Kč
  • GA ČR
Projekt

New regulators of megakaryocyte and erythroid lineage commitment (GAP305/10/0953)

the key regulators of cell fate determination by expression profiling usingDifferentiation of hematopoietic stem cells and progenitors into various and erythroid cells develop from a common myeloid progen...

EB - Genetika a molekulární biologie

  • 2010 - 2013
  • 5 167 tis. Kč
  • 5 167 tis. Kč
  • GA ČR
Projekt

Oxidatively damaged vital eukaryotic membrane proteins and their further fate yeast plasma membrane H+-ATPase (GA204/99/0488)

the further fate of oxidatively modified membrane proteins, and (4) determine the ways of diseases, in ageing, programmed cell death and apoptosis. No respiring cell escapes ROS toxics. In the project we will (1) ...

EB - Genetika a molekulární biologie

  • 1999 - 2001
  • 1 876 tis. Kč
  • 1 280 tis. Kč
  • GA ČR
Projekt

The role of c-myb gene in the early vertebrate embryogenesis (GA304/03/0463)

in gastrulation, neurulation and in the fate determination of multipotent cells the first part of the proposed work, c-myb expressing cells will be identified and their fate determined. Next, in ...

EA - Morfologické obory a cytologie

  • 2003 - 2005
  • 3 993 tis. Kč
  • 3 993 tis. Kč
  • GA ČR
Projekt

Deciphering pancreas development and function at the single-cell level (GA25-15876S)

Understanding the embryonic development of the pancreas, particularly cell fate decisions, endocrine cell differentiation, and functional maturation of endocrine cells fates. At the single cell le...

Developmental biology

  • 2025 - 2027
  • 11 748 tis. Kč
  • 11 748 tis. Kč
  • GA ČR
Projekt

Quantification and localization of maternal mRNAs in early development of Xenopus (KJB500520601)

and cell determination/fate. The maps will serve as a framework for studies of otherCell determination during early development is a process that directly depends on protein and mRNA cell content...

EB - Genetika a molekulární biologie

  • 2006 - 2007
  • 720 tis. Kč
  • 720 tis. Kč
  • AV ČR
Projekt

Role of hypoxia and intracellular redox status disbalance in a regulation of cell selfrenewal and differentiation (LD11015)

We suggest the key role of interaction between redox imbalance and cell fate directed signaling pathways. The cell fate thus may be modulated through specific are to evaluate effects of hypoxia and chemically induc...

ED - Fyziologie

  • 2011 - 2013
  • 1 915 tis. Kč
  • 1 915 tis. Kč
  • MŠMT
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