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119 (0,072s) •

Projekt

Gene src and Xenopus laevis development (GA301/02/0408)

of function of both the cellular (c-Src) and the viral (v-Src) form of Src tyrosine kinase (TK) in the cell. The main reason was the fact that activated forms of Src are oncogenic,Src and its relatives ar...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 10 830 tis. Kč
    • •
  • 4 325 tis. Kč
    • •
  • GA ČR
Projekt

Center of Cell Invasiveness in Embryonic Development and Tumour Metastases (LC06061)

The cells in multicellular organisms are spatially organized through cell-cell and cell-extracellular matrix interactions. Disruption of adhesive bonds results in enhanced cell motility and helps cells to become invasive - to degrade the basal membra...

FD - Onkologie a hematologie

  • 2006 - 2011
    • •
  • 64 683 tis. Kč
    • •
  • 64 683 tis. Kč
    • •
  • MŠMT
Projekt

Analysis of Src kinase activation using a novel FRET-based biosensor (GA15-07321S)

Src kinase is a well-known proto oncogene that plays crucial roles in migration in tumors. The current model for regulation of Src proposes a correlation between, the conformation loosens and Src kinase domain becomes activ...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 170 tis. Kč
    • •
  • 4 170 tis. Kč
    • •
  • GA ČR
Projekt

Study of inhibitory mechanisms of pp60c-src during induced differentiation of colorectal tumour cells (GA312/97/1188)

Changes in protein kinase activity of pp60c-src are not a sufficiently sensitive marker of c-src action and therefore the determination of more subtle differences connected with c-src function in cells is needed. Analysis o...

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 3 596 tis. Kč
    • •
  • 2 286 tis. Kč
    • •
  • GA ČR
Projekt

V-src oncogenes the dominant players in a hierarchy of events leading to cancer (GA204/02/0407)

V-src acts as a dominant gene transforming permissive cells in vitro. More strikingly, v-src triggers oncogenesis in vivo, even when inoculated as cloned DNA. To study src gene functions we have used an experimental model c...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 5 847 tis. Kč
    • •
  • 2 262 tis. Kč
    • •
  • GA ČR
Projekt

Gene src and related src family protein tyrosine kinases (PTK) involvement in cell signalling and differentiation and their pathogenic and oncogenic activities (GV312/96/K205)

which the protooncogene c-src operates. C-src not only acts as an organizer and mitosis. On the other hand a number of ways are known to be involved in c-src transformation to its oncogene, v-src. A new way leadin...

EB - Genetika a molekulární biologie

  • 1996 - 2001
    • •
  • 37 518 tis. Kč
    • •
  • 29 496 tis. Kč
    • •
  • GA ČR
Projekt

Control of mTOR and MAPK pathways by Src tyrosine kinase activity - implication for cancer therapy by protein kinase inhibitors (NT11231)

Tyrosine kinase activity of Src is up-regulated in numerous types of human cancer and Src inhibitors are used as efficient anticancer drugs. Pre-clinical data. Our previous findings has shown that the suppression of Src kin...

FD - Onkologie a hematologie

  • 2010 - 2013
    • •
  • 3 723 tis. Kč
    • •
  • 3 723 tis. Kč
    • •
  • MZ
Projekt

The role of PI3 kinase - mTOR signaling in CAS-mediated invasiveness of Src-transformed cells (GA301/06/1147)

and anchorage-independent growth of Src-transformed cells. Integrin-mediated signaling has been also implicated in Src-mediated transformation. Our results, as well as results of the other groups demonstrate integrin-associated

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 729 tis. Kč
    • •
  • 3 729 tis. Kč
    • •
  • GA ČR
Projekt

Signal transduction in lymphoid cells mediated by non-receptor protein tyrosine kinases of the Src and Syk families. (IZ3517)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 1 707 tis. Kč
    • •
  • 1 096 tis. Kč
    • •
  • MZ
Projekt

RNA interference applications in chickens (GA523/04/0569)

potential of oligonucleotide sequences against discrete genes, e.g. the v-src and c-src. Another application of these vectors will be the reversal of v-src-induced cell transformation in vitro of the regression of v-sr...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2004 - 2006
    • •
  • 3 153 tis. Kč
    • •
  • 3 153 tis. Kč
    • •
  • GA ČR
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