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1 479 (0,071s) •

Projekt

Pathophysiology of dystonia – role of gene-environment interaction and common pathophysiological pathways (8F20001)

) pathophysiologic pathways from the molecular to the brain network level using geneticallyThe EurDyscover consortium combines outstanding expertise from across Europe in molecular neurobiology, cellular and system pathophysiolo...

Other medical science

  • 2020 - 2024
    • •
  • 5 217 tis. Kč
    • •
  • 5 217 tis. Kč
    • •
  • MŠMT
Projekt

Pharmacological blockade of cytochrome P450 pathway as a new approach in hypertension treatment (NT11230)

The role of epoxyeicotrienoic acids in the pathophysiology of ANG II-dependent form of hypertension will be studied....

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2010 - 2013
    • •
  • 5 724 tis. Kč
    • •
  • 5 724 tis. Kč
    • •
  • MZ
Projekt

The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage posibilities of prevention and ragression of glomerulosclerosis. (NT12171)

The role of arachidonic acid metabolites in the pathophysiology of hypertensive organ damage will be studied via targeted inhibition of the enzyme catalyzing conversion of vasodilatory epoxyeicosatrienoic acids and via inhibition of vasocons...

FE - Ostatní obory vnitřního lékařství

  • 2011 - 2015
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  • 7 904 tis. Kč
    • •
  • 7 904 tis. Kč
    • •
  • MZ
Projekt

The role of interaction of the cytochrome P450-derived eicosanoids and the renin-angiotensin system in the pathophysiology of congestive heart failure combined with chronic kidney disease. (NT14012)

Recent studies have proposed that in the pathophysiology of progression of congestive heart failure combined with chronic kidney disease rather the interaction in the pathophysiology of congestive heart failure combined with the chr...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 5 211 tis. Kč
    • •
  • 5 211 tis. Kč
    • •
  • MZ
Projekt

Central and peripheral modulation of vascular tone and sodium excretion the role of brain and kidney in pathophysiology of hypertension (NV15-25396A)

hypertension (ß2-WNK4-NCC pathway). In contrast, renin-angiotensin system (RAS) is a major is to evaluate the role of these systems (especially ß2-WNK4-NCC pathway) in the development......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2019
    • •
  • 9 534 tis. Kč
    • •
  • 9 534 tis. Kč
    • •
  • MZ
Projekt

Morphological and pathophysiological changes of the retina and visual pathway in optic neuritis associated with multiple sclerosis (NV19-06-00216)

procedures provide insufficient data on patient prognosis, and the pathophysiological cortices in fMRI, and with subsequent structural changes in the optic pathways assessed......

Ophthalmology

  • 2019 - 2023
    • •
  • 7 458 tis. Kč
    • •
  • 7 458 tis. Kč
    • •
  • MZ
Projekt

on pathophysiology of salt-sensitive hypertension and renal injury (LH11116)

and its impact on pathophysiology of salt-sensitive and angiotensin II-dependent and cytochrome P450 pathway will be studied. The proposed studies will be tested folowing and thus may contribute to the pathophysiology of s...

ED - Fyziologie

  • 2011 - 2013
    • •
  • 1 120 tis. Kč
    • •
  • 1 120 tis. Kč
    • •
  • MŠMT
Projekt

The role of miRNA in development of glutamatergic and GABAergic signaling after early-life seizures (GA19-11931S)

later in life. Despite the extensive research, pathophysiological bases of both glutamatergic and γ-aminobutyric acid (GABA)ergic pathways play crucial role alterations of these pathways are involved in development of vari...

Developmental biology

  • 2019 - 2022
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  • 10 218 tis. Kč
    • •
  • 9 723 tis. Kč
    • •
  • GA ČR
Projekt

The role of neurosteroids in the etiopathogenesis of multiple sclerosis (NT13814)

as the ratio precursor / product in metabolic pathways. We expect that the proposed project will significantly contribute to the clarification of the pathophysiological mechanisms involved......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
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  • 4 302 tis. Kč
    • •
  • 4 302 tis. Kč
    • •
  • MZ
Projekt

European large-scale functional genomics in the rat for translational research (7E10067)

into the genes,molecular pathways and mechanisms underlying disease pathophysiology. The EU as a model system to identify the major functional pathways underlying human inflammatory......

EB - Genetika a molekulární biologie

  • 2010 - 2014
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  • 2 707 tis. Kč
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  • 2 707 tis. Kč
    • •
  • MŠMT
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