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Projekt

RECEPTOR - An agonist of adenosine A3 receptors in therapy of acute radiation diseas (OVBIOFYZ20101)

The project submitted is aimed at supplementing therapeutical approaches targeted at enhancing of regeneration of ionizing radiation-suppressed hematopoietic system with new therapeutical procedures deduced from the research area of adenosine membran...

FP - Ostatní lékařské obory

  • 2010 - 2012
    • •
  • 626 tis. Kč
    • •
  • 313 tis. Kč
    • •
  • MO
Projekt

Analysis of the metabolic effect of smoking accelerating atherogenesis in the Czech population (NJ6717)

Smoking deteriorates insulin sensitivity and increases serum TG levels. This effect may be more marked in the Czech population with extremely high levels of TG-rich lipoproteins and high rates of obesity. The adverse effect of smoking manifesting its...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2001 - 2004
    • •
  • 4 602 tis. Kč
    • •
  • 4 584 tis. Kč
    • •
  • MZ
Projekt

Autofluorescence and Early Detection of Malignity in Chronic Reflux Diseas of the Esophagus and in Barret's Esophagus (NC6771)

Endoscopicand histological detection of early malignant changes in the esophagus in GORD. Autofluorescence, its role and its comparison with chromoedoscopy. Correlation of the clinical findings with histology, flow cytometry and oncomarkers. Monitori...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 1 511 tis. Kč
    • •
  • 739 tis. Kč
    • •
  • MZ
Projekt

Microbial and host factors of development of invasive meningococcal disease (GV310/96/K102)

Applicants of three specialization (microbiology, immunology and infectology) will jointly analyze the relationships of microbial and host factors in the development of meningococcal invasive diseas. Special attention will be focused on the ...

EE - Mikrobiologie, virologie

  • 1996 - 2001
    • •
  • 23 945 tis. Kč
    • •
  • 19 002 tis. Kč
    • •
  • GA ČR
Projekt

Predictive value of adipokines in rheuamtoid arthritis (NS10614)

of the diseas will be assessed. Annotation III: The effect(s) of selected adipokines (mostly...

FE - Ostatní obory vnitřního lékařství

  • 2009 - 2011
    • •
  • 6 816 tis. Kč
    • •
  • 6 816 tis. Kč
    • •
  • MZ
Projekt

The changes of sympathetic function in subcutaneous adipose tissue in endocrine diseaes. Understanding of pathogenesis and importance for clinical medicine (NB7569)

The aim of the project is to evaluate local activity of sympathetic nervous systém and specific changes in metabolism of catechols in the adipose tissue. The local sympathetic function will be evaluated using clinical microdialysis. Concentration of ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 3 714 tis. Kč
    • •
  • 3 396 tis. Kč
    • •
  • MZ
Projekt

Senescence cells elimination in minimal residual tumour disease therapy (NT14461)

Interactions of tumour cells with the immune system are influenced by chemotherapy with genotoxic or tumour cell senescence-inducing effects leading to increased tumour cells sensitivity to immune responses. Subsequent immunotherapy could be very eff...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 094 tis. Kč
    • •
  • 7 094 tis. Kč
    • •
  • MZ
Projekt

Correlation of Helicobacter pylori and gastroesophageal rephlux to etiopathogenesis of oropharyngeal and laryngeal tumors (NT11523)

H. pylori was detected in saliva, dental plaque and oropharyngeal lymphatic tissue recently. Its pathogenetic role in oropharyngeal area remains unclear. GERD (gastroesophageal reflux disease) means the mucosal damage caused by reflux of acid gastric...

FF - ORL, oftalmologie, stomatologie

  • 2010 - 2015
    • •
  • 10 202 tis. Kč
    • •
  • 10 202 tis. Kč
    • •
  • MZ
Projekt

Progress in methods of laboratory diagnostics of inherited lysosomal neurodegenerative disorders (NT14015)

Lysosomal storage disorders (LSD) are severe hereditary diseases caused by defect in the function of enzyme or noncatalytic protein due to mutation of the corresponding gene. Most of them are associated with a progressive neurodegeneration. Early dia...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013 - 2015
    • •
  • 6 044 tis. Kč
    • •
  • 5 939 tis. Kč
    • •
  • MZ
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