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Filtry

524 (0,071s) •

Projekt

Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics (GP305/05/P156)

prevention of these damages using novel iron chelators of the aroylhydrazone group. These substances are lipophilic, they readily cross cell membranes and posses high iron-chelating efficacy. An in vitro model for...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 1 184 tis. Kč
    • •
  • 1 184 tis. Kč
    • •
  • GA ČR
Projekt

Efficient killing of cancer cells via mitochondrial targeting of iron chelators (GA18-13103S)

Cancer cells require iron as a critical cofactor for their proliferation, DNA synthesis and metabolic reactions. The role of iron in carcinogenesis is widely accepted and iron chelation leads to apoptosis induction...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 7 144 tis. Kč
    • •
  • 7 144 tis. Kč
    • •
  • GA ČR
Projekt

Iron-chelating polymer microparticles (GA19-01438S)

accumulation of iron in parenchymal organs. It can be caused by mutations in any gene that limits iron entry into the blood. Limiting iron uptake would thus be a way to treat hemochromatosis. The mechanism of iron...

Hematology

  • 2019 - 2021
    • •
  • 8 901 tis. Kč
    • •
  • 8 754 tis. Kč
    • •
  • GA ČR
Projekt

Anti-tumor effects of chelation therapy in myelodysplastic syndrome and identification of new therapeutic biomarkers. (NV16-31689A)

to iron chelator in vitro. In vivo, 6-week applications of chelator to preleukemia: to elucidate how iron chelation reinforces DDR and cell cycle checkpoints in oncogene patients are typically transfusion...

FD - Onkologie a hematologie

  • 2016 - 2020
    • •
  • 9 877 tis. Kč
    • •
  • 9 665 tis. Kč
    • •
  • MZ
Projekt

Mitochondrial biogenesis of iron-sulfur centers as a therapeutic target against infections and diseases (LUC24134)

Identification of specific and targeted chelators of mitochondrial iron and description of their effect on the biogenesis of iron-sulphur centres......

Microbiology

  • 2024 - 2026
    • •
  • 4 843 tis. Kč
    • •
  • 4 843 tis. Kč
    • •
  • MŠMT
Projekt

Personalized treatment of chronic myeloproliferative disorders and myelodysplastic syndrome - a cellular metabolomics study. (NT12218)

inhibitors or iron chelators enable to identify metabolomic markers of optimal treatment response and resistance and mechanisms by which iron chelators influence the cell cycle......

FR - Farmakologie a lékárnická chemie

  • 2011 - 2014
    • •
  • 6 631 tis. Kč
    • •
  • 6 631 tis. Kč
    • •
  • MZ
Projekt

Cardiovascular, Potentially Cardioprotective and Biotransformational Effects of New Iron Chelating Agents. (GA305/03/1511)

Iron plays a key role in the in vivo formation of oxyradicals, which-chelating agents. These lipophilic substances cross biological membranes, posses high Fe chelating efficacy, relatively low toxicity, and are very effecti...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 3 445 tis. Kč
    • •
  • 3 445 tis. Kč
    • •
  • GA ČR
Projekt

New iron chelators - problems of their cardiovascular, potential cardioprotective and biotransformation effects (GA305/00/0365)

Iron plays a key role in the in vivo formation of oxyradicals, which)belong among new effective Fe-chelating agents. These lipophilic substances cross biological membranes -they posses high Fe chelating efficiancy, relativl...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 4 975 tis. Kč
    • •
  • 4 495 tis. Kč
    • •
  • GA ČR
Projekt

Hemopoietic cell growth inhibition by iron chelating agents (IZ3565)

FP - Ostatní lékařské obory

  • 1996 - 1998
    • •
  • 1 393 tis. Kč
    • •
  • 1 393 tis. Kč
    • •
  • MZ
Projekt

New approaches to ciagnosis and treatment of hemolytic disorders (IZ4411)

in the hemolysisin hereditary hemoglobin disorders with membrane iron surplus and evaluation of treatment of iron overload using iron chelators sumultaneously with erythropoietin.......

FD - Onkologie a hematologie

  • 1997 - 1999
    • •
  • 5 814 tis. Kč
    • •
  • 4 319 tis. Kč
    • •
  • MZ
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