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36 716 (0,112s)

Výsledek výzkumu

Complex regulatory element within the E- and F-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid.

A new regulatory element recognized by Pax6 and the alernatively spliced Pax6(5a) isoform was identified within an enhancer region of E- and F-crystallin genes. Mutation of the Pax6 binding site, which is adjacent to a retinoic acid...

EB - Genetika a molekulární biologie

  • 2002
  • Jx
Výsledek výzkumu

System solving of road-traffic safety problems

was characterized: purpose of system, i. e. aim, or more precisely aim behaviour system, systems structure, i. e. system element and bindings between them, characteristics ofsystem element significant to general behaviour ...

JO - Pozemní dopravní systémy a zařízení

  • 2007
  • D
Výsledek výzkumu

Long-residency hydration, cation binding and dynamics of Loop E/Helix IV rRNA - L25 protein complex

Internal loops are common elements of RNA secondary structure. They often form binding sites for metals, proteins and other RNAs. To under-stand the effects of internal loops on RNA structure and function, we have carried out molecular dynam...

BO - Biofyzika

  • 2004
  • Jx
Výsledek výzkumu

Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

MHC-E regulates NK cells by displaying MHC class Ia signal peptides (VL9) to NKG2A:CD94 receptors. MHC-E can also present sequence-diverse, lower-affinity, pathogen these affinity differences, human MHC-E (HLA-E)-V...

Immunology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

The pi-Helix Formation between Asp(369) and Thr(375) as a Key Factor in E-1-E-2 Conformational Change of Na+/K+-ATPase

H4-H5-loop structure of Na+/K+-ATPase in E1 and E2 conformations was studied by molecular modeling. E1-E2 transition is connected with ?-helix formation (Asp369?Thr375) and distance-shortening between the ATP binding and phosphorylation site...

ED - Fyziologie

  • 2009
  • Jx
Výsledek výzkumu

Vector (17F2KHC) for expression of the microtubule-binding domain of the human neuronal kinesin (nKHC) heavy chain in E. coli

The bacterial expression vector carrying the cDNA of the microtubule-binding domain of the human neuronal kinesin (nKHC) heavy chain was constructed using recombinant DNA methods. For an easier purification, the insert carries the N-terminal...

EE - Mikrobiologie, virologie

  • 2007
  • X
Výsledek výzkumu

Transcription factor binding at Ig enhancers is linked to somatic hypermutation targeting

lambda enhancer and/or the IgH intronic enhancer (E mu) in vivo. Further investigation using SHM reporter assays identified binding sites for E2A and MEF2B in E mu and demonstrated an association between loss of factor

Immunology

  • 2020
  • Jimp
  • Odkaz
Výsledek výzkumu

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

The non-classical class Ib molecule human leukocyte antigen E (HLA-E) has limited polymorphism and can bind HLA class Ia leader peptides (VL9). HLA-E-VL9-E-VL9-specific IgM antibody that enhances killing o...

Immunology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

Binding-competent states for L-arginine in E. coli arginine repressor apoprotein

Arginine repressor of E. coli is a multifunctional hexameric protein cooperative binding of L-arginine. Interpretation of this complex system requires and absence of the six L-arg ligands that bind at the trimer-trimer inte...

CE - Biochemie

  • 2014
  • Jx
  • Odkaz
Výsledek výzkumu

Colonization factor CS30 from enterotoxigenic Escherichia coli binds to sulfatide in human and porcine small intestine

colonization factor CS30 were examined by binding of CS30-expressing bacteria to glycosphingolipids on thin-layer chromatograms. We thereby found a highly specific binding and porcine small intestine, while no binding was ...

Microbiology

  • 2020
  • Jimp
  • Odkaz
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