Úloha genetických faktorů v patogenezi alkoholického onemocnění jater

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F04%3A00001076" target="_blank" >RIV/00023001:_____/04:00001076 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Role of genetic factors in the pathogenesis of alcoholic liver disease

Popis výsledku v původním jazyce

Excessive alcohol intake leads to liver disease, which can range from simple steatosis to steatohepatitis, fi brosis, and/or cirrhosis. While steatosis develops in most regular drinkers, the vast majority do not develop more severe liver damage; the reasons for this are largelyunknown, but may include both environmental and genetic factors. Earlier data from retrospective epidemiological studies are confl icting, raising doubts over the relationship between alcohol consumption and the risk of liver disease. In contrast, recent prospective studies provide evidence for both a threshold effect and a dose-response relationship, suggesting that the minimum alcohol quantity that confers a measurable risk of developing alcoholic cirrhosis is 30 g ethanol perday and that the cumulative lifetime alcohol intake leading to cirrhosis is 100 kg of pure ethanol. In addition, men and women who consume more than 80 g/d of ethanol have an equal risk for cirrhosis. According to these data, less than 5%

Název v anglickém jazyce

Role of genetic factors in the pathogenesis of alcoholic liver disease

Popis výsledku anglicky

Excessive alcohol intake leads to liver disease, which can range from simple steatosis to steatohepatitis, fi brosis, and/or cirrhosis. While steatosis develops in most regular drinkers, the vast majority do not develop more severe liver damage; the reasons for this are largelyunknown, but may include both environmental and genetic factors. Earlier data from retrospective epidemiological studies are confl icting, raising doubts over the relationship between alcohol consumption and the risk of liver disease. In contrast, recent prospective studies provide evidence for both a threshold effect and a dose-response relationship, suggesting that the minimum alcohol quantity that confers a measurable risk of developing alcoholic cirrhosis is 30 g ethanol perday and that the cumulative lifetime alcohol intake leading to cirrhosis is 100 kg of pure ethanol. In addition, men and women who consume more than 80 g/d of ethanol have an equal risk for cirrhosis. According to these data, less than 5%

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World gastroenterology news

ISSN

1567-7753

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

2

Strana od-do

11-12

Kód UT WoS článku

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EID výsledku v databázi Scopus

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