Antibody Responses in Immunosuppressed Organ Allograft Recipients - Brief Review of the Current Literature

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F09%3A00002169" target="_blank" >RIV/00023001:_____/09:00002169 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antibody Responses in Immunosuppressed Organ Allograft Recipients - Brief Review of the Current Literature

Popis výsledku v původním jazyce

With the rapidly growing application of new highly sensitive techniques for detection and definition of antibodies specific to HLA and non?HLA antigens, a significant number of studies have reported that de novo generation of antibodies after organ transplantation is associated with severe immunological complications and graft loss. The presence of donor specific complement?binding antibodies is confirmed by the finding of C4d deposits in the peritubular capillaries of the kidney graft ? a method now regularly used as a marker of antibody-mediated rejection. The clinical significance of various techniques for antibody identification with respect to the incidence of organ transplant rejection is however still a matter of discussion. The discrepancies inthe literature are most likely caused by variations in the approaches for antibody characterization and differences in patient cohorts and immunosuppressive protocols. In this concise review, we will discuss some recent developments in t

Název v anglickém jazyce

Antibody Responses in Immunosuppressed Organ Allograft Recipients - Brief Review of the Current Literature

Popis výsledku anglicky

With the rapidly growing application of new highly sensitive techniques for detection and definition of antibodies specific to HLA and non?HLA antigens, a significant number of studies have reported that de novo generation of antibodies after organ transplantation is associated with severe immunological complications and graft loss. The presence of donor specific complement?binding antibodies is confirmed by the finding of C4d deposits in the peritubular capillaries of the kidney graft ? a method now regularly used as a marker of antibody-mediated rejection. The clinical significance of various techniques for antibody identification with respect to the incidence of organ transplant rejection is however still a matter of discussion. The discrepancies inthe literature are most likely caused by variations in the approaches for antibody characterization and differences in patient cohorts and immunosuppressive protocols. In this concise review, we will discuss some recent developments in t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9403" target="_blank" >NR9403: DIAGNOSTIKA HUMORÁLNÍ REJEKCE PRO TRANSPLANTACE ORGÁNŮ</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Immunology Reviews

ISSN

1573-3955

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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