Autocrine effects of visfatin on hepatocyte sensitivity to insulin action
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F10%3A00002297" target="_blank" >RIV/00023001:_____/10:00002297 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/10:00347884 RIV/61388971:_____/10:00347884 RIV/60461373:22330/10:00024459
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Autocrine effects of visfatin on hepatocyte sensitivity to insulin action
Popis výsledku v původním jazyce
Visfatin was originally described as an adipokine with insulin mimetic effects. Recently, it was found that visfatin is identical with the Nampt (nicotinamide phosphoribosyltransferase) gene that codes for an intra- and extracellular NAD biosynthetic enzyme and is predominantly expressed outside adipose tissue. In the current study, we found strong protein and mRNA expression of visfatin in rat heart, liver, kidney, and muscle while the expression of visfatin in visceral fat was significantly lower andundetectable in subcutaneous fat. The insulin-mimetic effects on visfatin (extracellular form of Nampt or eNampt) are controversial and even less is known about autocrine effects of visfatin (intracellular form of Nampt or iNampt). Since liver plays themajor role in glucose metabolism, we studied visfatin effects on insulin stimulated cellular glucose uptake in Fao rat hepatocytes using RNA interference (RNAi). RNAi mediated down regulation of the visfatin expression in Fao cells was as
Název v anglickém jazyce
Autocrine effects of visfatin on hepatocyte sensitivity to insulin action
Popis výsledku anglicky
Visfatin was originally described as an adipokine with insulin mimetic effects. Recently, it was found that visfatin is identical with the Nampt (nicotinamide phosphoribosyltransferase) gene that codes for an intra- and extracellular NAD biosynthetic enzyme and is predominantly expressed outside adipose tissue. In the current study, we found strong protein and mRNA expression of visfatin in rat heart, liver, kidney, and muscle while the expression of visfatin in visceral fat was significantly lower andundetectable in subcutaneous fat. The insulin-mimetic effects on visfatin (extracellular form of Nampt or eNampt) are controversial and even less is known about autocrine effects of visfatin (intracellular form of Nampt or iNampt). Since liver plays themajor role in glucose metabolism, we studied visfatin effects on insulin stimulated cellular glucose uptake in Fao rat hepatocytes using RNA interference (RNAi). RNAi mediated down regulation of the visfatin expression in Fao cells was as
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
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Svazek periodika
59
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
4
Strana od-do
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Kód UT WoS článku
000282054700016
EID výsledku v databázi Scopus
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