MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002472" target="_blank" >RIV/00023001:_____/11:00002472 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10334-011-0264-9" target="_blank" >http://dx.doi.org/10.1007/s10334-011-0264-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10334-011-0264-9" target="_blank" >10.1007/s10334-011-0264-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients

Popis výsledku v původním jazyce

Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction fat in a group of liver transplant patients,an at-risk group for the development of de novo steatosis. Linear and non-linear regression models were used to describe the relationship between fat and His. Strong correlation was found for both models with r =0.83-0.94 (p<0.001); a higher r was foundfor non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His >= 5% and >33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of fat and different slopes were obtained for fibrosis stage F0-F1 and F2-F3, respectively. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fa

Název v anglickém jazyce

MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients

Popis výsledku anglicky

Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction fat in a group of liver transplant patients,an at-risk group for the development of de novo steatosis. Linear and non-linear regression models were used to describe the relationship between fat and His. Strong correlation was found for both models with r =0.83-0.94 (p<0.001); a higher r was foundfor non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His >= 5% and >33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of fat and different slopes were obtained for fibrosis stage F0-F1 and F2-F3, respectively. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Magnetic resonance materials in physics, biology and medicine

ISSN

0968-5243

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

297-304

Kód UT WoS článku

000295177400005

EID výsledku v databázi Scopus

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