Effect of tacrolimus versus cyklosporine on glukose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002529" target="_blank" >RIV/00023001:_____/11:00002529 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S004113451101339X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S004113451101339X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2011.09.060" target="_blank" >10.1016/j.transproceed.2011.09.060</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of tacrolimus versus cyklosporine on glukose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period

Popis výsledku v původním jazyce

Diabetogenic effects of immunosuppressive agents are of great importance in pancreas or islet transplantation. The aim of our study was to compare the glucose metabolism in type 1 diabetic kidney and pancreas recipients on tacrolimus (Tacro) versus cyclosporine-based (Cyclo) immunosuppression in the late posttransplant period. We examined 26 insulinindependent patients with stabile good renal function. They were at least 7 years after simultaneous pancreas and kidney transplantation and with unchanged immunosuppressive therapy for at least 6 years. The mean follow-up in Tacro (n 13) and Cyclo (n 13) groups were 9.7 1.9 and 10.9 1.3 years, respectively (P .08). Fasting glycemia, insulin levels, glycosylated hemoglobin (HbA1c), a standard intravenous glucose tolerance test (IVGTT) with coefficient of glucose assimilation (KG) calculation and trough Tacro/Cyclo levels were assessed. Insulin sensitivity and insulin secretion were evaluated using the homeostasis model assessment (HOMA-IR, H

Název v anglickém jazyce

Effect of tacrolimus versus cyklosporine on glukose metabolism of pancreas and kidney recipients in the late (> 8 years) posttransplant period

Popis výsledku anglicky

Diabetogenic effects of immunosuppressive agents are of great importance in pancreas or islet transplantation. The aim of our study was to compare the glucose metabolism in type 1 diabetic kidney and pancreas recipients on tacrolimus (Tacro) versus cyclosporine-based (Cyclo) immunosuppression in the late posttransplant period. We examined 26 insulinindependent patients with stabile good renal function. They were at least 7 years after simultaneous pancreas and kidney transplantation and with unchanged immunosuppressive therapy for at least 6 years. The mean follow-up in Tacro (n 13) and Cyclo (n 13) groups were 9.7 1.9 and 10.9 1.3 years, respectively (P .08). Fasting glycemia, insulin levels, glycosylated hemoglobin (HbA1c), a standard intravenous glucose tolerance test (IVGTT) with coefficient of glucose assimilation (KG) calculation and trough Tacro/Cyclo levels were assessed. Insulin sensitivity and insulin secretion were evaluated using the homeostasis model assessment (HOMA-IR, H

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

—

Svazek periodika

43

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

3270-3272

Kód UT WoS článku

000297485500031

EID výsledku v databázi Scopus

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