Statistical bias in seeking the left ventricular endocardial sweet spot for cardiac resychronization therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002775" target="_blank" >RIV/00023001:_____/11:00002775 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0735109710048266" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0735109710048266</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacc.2010.09.060" target="_blank" >10.1016/j.jacc.2010.09.060</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Statistical bias in seeking the left ventricular endocardial sweet spot for cardiac resychronization therapy

Popis výsledku v původním jazyce

The letter is challenging the conclusions of the two studies in patients with ischemic cardiomyopathy (Spragg DD et al. J Am Coll Cardiol 2010;56:774-81 and Derval N et al. J Am Coll Cardiol 2010;55:566-75) which reported that left ventricular endocardial pacing used for resynchronization therapy is capable of dramatic improvements in left ventricular systolic function compared to conventional epicardial pacing. Left ventricular sweet spot was sought among a considerable number of left ventricular endocardial sites in these studies and the correction for multiple measurements design was not performed. We demonstrated by mathematical modeling that a relatively small measurement error projects into a rather wide range of extreme hemodynamic indices resulting in significant overestimation of hemodynamic impact of pacing from the "optimum" site. It was concluded that an endocardial approach to cardiac resynchronization is a promising concept, but adequate experimental design and correct da

Název v anglickém jazyce

Statistical bias in seeking the left ventricular endocardial sweet spot for cardiac resychronization therapy

Popis výsledku anglicky

The letter is challenging the conclusions of the two studies in patients with ischemic cardiomyopathy (Spragg DD et al. J Am Coll Cardiol 2010;56:774-81 and Derval N et al. J Am Coll Cardiol 2010;55:566-75) which reported that left ventricular endocardial pacing used for resynchronization therapy is capable of dramatic improvements in left ventricular systolic function compared to conventional epicardial pacing. Left ventricular sweet spot was sought among a considerable number of left ventricular endocardial sites in these studies and the correction for multiple measurements design was not performed. We demonstrated by mathematical modeling that a relatively small measurement error projects into a rather wide range of extreme hemodynamic indices resulting in significant overestimation of hemodynamic impact of pacing from the "optimum" site. It was concluded that an endocardial approach to cardiac resynchronization is a promising concept, but adequate experimental design and correct da

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American College of Cardiology

ISSN

0735-1097

e-ISSN

—

Svazek periodika

57

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

1000

Kód UT WoS článku

000287650900021

EID výsledku v databázi Scopus

—