Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056070" target="_blank" >RIV/00023001:_____/12:00056070 - isvavai.cz</a>

Výsledek na webu

<a href="http://journals.lww.com/asaiojournal/pages/articleviewer.aspx?year=2012&issue=11000&article=00005&type=abstract" target="_blank" >http://journals.lww.com/asaiojournal/pages/articleviewer.aspx?year=2012&issue=11000&article=00005&type=abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MAT.0b013e31826d6070" target="_blank" >10.1097/MAT.0b013e31826d6070</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome

Popis výsledku v původním jazyce

Left ventricular assist devices (LVADs) have become an established surgical therapy for patients with end-stage heart failure who require hemodynamic support as a bridge-to-transplant or destination therapy. However, the anatomic and physiologic consequences of long-term LVAD support have yet to be fully clarified. Despite the clinical success of these devices, it has been reported that many patients bridged to transplantation with mechanical support develop circulating antibodies with potential donor reactivity. Transplanting against existing or historic donor-specific antibodies is associated with increased risk of antibody-mediated rejection, graft dysfunction, and decreased survival. Safe transplantation of allosensitized patients is dependent on using prospective crossmatching and antibody titer reduction techniques (desensitization). Strict protocols requiring a negative prospective crossmatch before transplantation result in a decreased donor pool and a longer duration of suppor

Název v anglickém jazyce

Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome

Popis výsledku anglicky

Left ventricular assist devices (LVADs) have become an established surgical therapy for patients with end-stage heart failure who require hemodynamic support as a bridge-to-transplant or destination therapy. However, the anatomic and physiologic consequences of long-term LVAD support have yet to be fully clarified. Despite the clinical success of these devices, it has been reported that many patients bridged to transplantation with mechanical support develop circulating antibodies with potential donor reactivity. Transplanting against existing or historic donor-specific antibodies is associated with increased risk of antibody-mediated rejection, graft dysfunction, and decreased survival. Safe transplantation of allosensitized patients is dependent on using prospective crossmatching and antibody titer reduction techniques (desensitization). Strict protocols requiring a negative prospective crossmatch before transplantation result in a decreased donor pool and a longer duration of suppor

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ASAIO Journal

ISSN

1058-2916

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

554-561

Kód UT WoS článku

000310580400005

EID výsledku v databázi Scopus

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