A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056313" target="_blank" >RIV/00023001:_____/12:00056313 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0002961011002601/1-s2.0-S0002961011002601-main.pdf?_tid=608d44861aa4c1b772ad480720a70753&acdnat=1342609987_5f154cc09aa9b37bb491144999049c7a" target="_blank" >http://ac.els-cdn.com/S0002961011002601/1-s2.0-S0002961011002601-main.pdf?_tid=608d44861aa4c1b772ad480720a70753&acdnat=1342609987_5f154cc09aa9b37bb491144999049c7a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amjsurg.2011.02.009" target="_blank" >10.1016/j.amjsurg.2011.02.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence

Popis výsledku v původním jazyce

BACKGROUND: The greater omentum with its vascularization and blood flow has been considered as a location for islet transplantation; however, there is a need to provide a controlled and protected site for the islets within the omentum that would be applicable to donor islets and future stem cell technologies. Here we describe the use of a novel device implanted within the omentum with a subcutaneous delivery port that offers an environment for donor islets. METHODS: A prototype cell pouch device was wrapped in the greater omentum and an islet implantation port was exposed subcutaneously in diabetic Lewis rats. After tissue growth throughout the device, islet isografts were implanted and long-term glucose control was evaluated. RESULTS: By using this technique, 7 of 10 diabetic rat recipients showed long-term normal blood glucose levels after minimal islet dose transplants. Histologic assessment revealed collagen formation and vascularization within the device. CONCLUSIONS: The implante

Název v anglickém jazyce

A novel technique for the transplantation of pancreatic islets within a vascularized device into the greater omentum to achieve insulin independence

Popis výsledku anglicky

BACKGROUND: The greater omentum with its vascularization and blood flow has been considered as a location for islet transplantation; however, there is a need to provide a controlled and protected site for the islets within the omentum that would be applicable to donor islets and future stem cell technologies. Here we describe the use of a novel device implanted within the omentum with a subcutaneous delivery port that offers an environment for donor islets. METHODS: A prototype cell pouch device was wrapped in the greater omentum and an islet implantation port was exposed subcutaneously in diabetic Lewis rats. After tissue growth throughout the device, islet isografts were implanted and long-term glucose control was evaluated. RESULTS: By using this technique, 7 of 10 diabetic rat recipients showed long-term normal blood glucose levels after minimal islet dose transplants. Histologic assessment revealed collagen formation and vascularization within the device. CONCLUSIONS: The implante

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of surgery

ISSN

0002-9610

e-ISSN

—

Svazek periodika

203

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

793-797

Kód UT WoS článku

000305471600020

EID výsledku v databázi Scopus

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