The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in general population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056415" target="_blank" >RIV/00023001:_____/12:00056415 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/12:00009878

Výsledek na webu

<a href="http://ndt.oxfordjournals.org/content/27/3/1030.full" target="_blank" >http://ndt.oxfordjournals.org/content/27/3/1030.full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfr418" target="_blank" >10.1093/ndt/gfr418</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in general population

Popis výsledku v původním jazyce

Background. Genome-wide association studies identified the FTO (fat mass and obesity gene) gene as an important determinant of body weight. More recently, the FTO gene was reported to be associated with other outcomes, including major risk factors for chronic kidney disease (CKD). We investigated the role of this gene in the risk of end-stage renal disease (ESRD) caused by CM). Methods. We conducted two large population-based case control studies of ESRD. Study 1 compared 984 haemodialysed patients withESRD with 2501 participants in the Czech post-MONICA study; Study 2 compared 1188 patients included in a kidney transplantation programme for ESRD with 6681 participants in the Czech HAPIEE study. The frequencies of the FTO rs17817449 single nucleotidepolymorphism genotype were compared between cases and controls. Results. The FTO rs17817449 genotype was significantly associated with CKD in both studies (P-values 0.00004 and 0.006, respectively). In the pooled data, the odds ratios of

Název v anglickém jazyce

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in general population

Popis výsledku anglicky

Background. Genome-wide association studies identified the FTO (fat mass and obesity gene) gene as an important determinant of body weight. More recently, the FTO gene was reported to be associated with other outcomes, including major risk factors for chronic kidney disease (CKD). We investigated the role of this gene in the risk of end-stage renal disease (ESRD) caused by CM). Methods. We conducted two large population-based case control studies of ESRD. Study 1 compared 984 haemodialysed patients withESRD with 2501 participants in the Czech post-MONICA study; Study 2 compared 1188 patients included in a kidney transplantation programme for ESRD with 6681 participants in the Czech HAPIEE study. The frequencies of the FTO rs17817449 single nucleotidepolymorphism genotype were compared between cases and controls. Results. The FTO rs17817449 genotype was significantly associated with CKD in both studies (P-values 0.00004 and 0.006, respectively). In the pooled data, the odds ratios of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NR7958" target="_blank" >NR7958: Genetická podstata komplikace hemodialyzační léčby - syndromu MIA (Malnutrition-Inflammation-Atherosclerosis)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nephrology Dialysis Transplantation

ISSN

0931-0509

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1030-1035

Kód UT WoS článku

000301907200028

EID výsledku v databázi Scopus

—