B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00057600" target="_blank" >RIV/00023001:_____/13:00057600 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/TP.0b013e3182789a24" target="_blank" >http://dx.doi.org/10.1097/TP.0b013e3182789a24</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/TP.0b013e3182789a24" target="_blank" >10.1097/TP.0b013e3182789a24</a>

Jazyk výsledku

angličtina

Název v původním jazyce

B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients

Popis výsledku v původním jazyce

Background: Molecular signatures have recently been identified in operationally tolerant long-term kidney transplant patients; however, their expression in patients on immunosuppression remains unclear. Methods. In this prospective study, the gene expression profiles of eight selected tolerance-associated genes (MS4A1, CD79B, TCL1A, TMEM176B, FOXP3, TOAG-1, MAN1A1, and TLR5) in the peripheral blood of 67 kidney transplant recipients at days 0, 7, 14, 21, 28, 60, 90, and at 6 and 12 months, and in graftbiopsies were measured. Similarly, using flow cytometry, CD45(+)CD19(+)CD3(-) B-cell counts were evaluated in the follow-up. Expression patterns were compared among patients with biopsy-proven acute rejection, borderline changes, and in rejection-free patients. A generalized linear mixed model with gamma distribution for repeated measures adjusted for induction therapy was used for statistical analysis of longitudinal data and Kruskal-Wallis test for case biopsy data. Results. Compared t

Název v anglickém jazyce

B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients

Popis výsledku anglicky

Background: Molecular signatures have recently been identified in operationally tolerant long-term kidney transplant patients; however, their expression in patients on immunosuppression remains unclear. Methods. In this prospective study, the gene expression profiles of eight selected tolerance-associated genes (MS4A1, CD79B, TCL1A, TMEM176B, FOXP3, TOAG-1, MAN1A1, and TLR5) in the peripheral blood of 67 kidney transplant recipients at days 0, 7, 14, 21, 28, 60, 90, and at 6 and 12 months, and in graftbiopsies were measured. Similarly, using flow cytometry, CD45(+)CD19(+)CD3(-) B-cell counts were evaluated in the follow-up. Expression patterns were compared among patients with biopsy-proven acute rejection, borderline changes, and in rejection-free patients. A generalized linear mixed model with gamma distribution for repeated measures adjusted for induction therapy was used for statistical analysis of longitudinal data and Kruskal-Wallis test for case biopsy data. Results. Compared t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation

ISSN

0041-1337

e-ISSN

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Svazek periodika

95

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

148-154

Kód UT WoS článku

000313058700022

EID výsledku v databázi Scopus

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