Prediction of organ transplant rejection by HLA-specific and non-HLA antibodies brief literature review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00057908" target="_blank" >RIV/00023001:_____/13:00057908 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2012.01139.x/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1744-313X.2012.01139.x/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1744-313X.2012.01139.x" target="_blank" >10.1111/j.1744-313X.2012.01139.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prediction of organ transplant rejection by HLA-specific and non-HLA antibodies brief literature review

Popis výsledku v původním jazyce

The application of soli-phase assays for detection and definition of Human luecocyty antigen (HLA)- specific antibodies has significantly facilitated the diagnosis and monitoring of treatment of antibody-mediated tejection (AMR). There is, however, a major discusion in the literature concerning the clinical relevance of the use of the Luminex technique for the prediction of celluar and/or AMR and survival. This may be explained on one hand by the complexities of the method and on the other by variationsin patient demographic charakteristics, immunosuppression and other factors. As far as non-HLA antibodies, it is clear that they may induce AMR; nevertheless,a difficult problem in their definition remains the fact that most of the non-HLA antigens still remain to be identified. Hereby is a short literature review of several recent publications discussing the role of HLA- and non-HLA-specific antibodies in organ transplant rejection and survival.

Název v anglickém jazyce

Prediction of organ transplant rejection by HLA-specific and non-HLA antibodies brief literature review

Popis výsledku anglicky

The application of soli-phase assays for detection and definition of Human luecocyty antigen (HLA)- specific antibodies has significantly facilitated the diagnosis and monitoring of treatment of antibody-mediated tejection (AMR). There is, however, a major discusion in the literature concerning the clinical relevance of the use of the Luminex technique for the prediction of celluar and/or AMR and survival. This may be explained on one hand by the complexities of the method and on the other by variationsin patient demographic charakteristics, immunosuppression and other factors. As far as non-HLA antibodies, it is clear that they may induce AMR; nevertheless,a difficult problem in their definition remains the fact that most of the non-HLA antigens still remain to be identified. Hereby is a short literature review of several recent publications discussing the role of HLA- and non-HLA-specific antibodies in organ transplant rejection and survival.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11262" target="_blank" >NT11262: Přístup k pacientům s preformovanými protilátkami před transplantací srdce.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of immunogenetics

ISSN

1744-3121

e-ISSN

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Svazek periodika

40

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

83-87

Kód UT WoS článku

000315966400001

EID výsledku v databázi Scopus

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