IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058738" target="_blank" >RIV/00023001:_____/13:00058738 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/13:00396456 RIV/00064190:_____/13:#0000588

Výsledek na webu

<a href="http://ac.els-cdn.com/S0198885913002127/1-s2.0-S0198885913002127-main.pdf?_tid=2e72e306-745d-11e3-84cd-00000aab0f27&acdnat=1388743111_c3cc3a8127cf51b1e24bdc17b1abaf1c" target="_blank" >http://ac.els-cdn.com/S0198885913002127/1-s2.0-S0198885913002127-main.pdf?_tid=2e72e306-745d-11e3-84cd-00000aab0f27&acdnat=1388743111_c3cc3a8127cf51b1e24bdc17b1abaf1c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.humimm.2013.07.011" target="_blank" >10.1016/j.humimm.2013.07.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis

Popis výsledku v původním jazyce

Aims: We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. Patients and methods: 46 IPF patientsunderwent genotyping, 43 of them had HRCT and 14 patients had a surgical lung biopsy. The HRCT scans were evaluated for AS and IS. The histopathological evaluation comprised myofibroblast foci (MF), intensity of inflammation and fibrosis (Ashcroft score)and numbers of eosinophils and granulomas. For immunohistochemical evaluation primary antibodies against PAR-2, CD124, TGF beta, YY-1 and TSLP were used. The IL-4 and IL-4 R alpha gene polymorphisms were characterized. Results: We found a correlation between eosinophils in lung biopsies and AS. The Ashcroft score was higher in IL-4 HA 2 GCC and MF were more frequent in IL-4 HA 2 TCC carriers. A relationship was found between IL-4 (-1098) A2 T and PAR-2 expression and IL-4 (-590) A1 T, I

Název v anglickém jazyce

IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis

Popis výsledku anglicky

Aims: We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. Patients and methods: 46 IPF patientsunderwent genotyping, 43 of them had HRCT and 14 patients had a surgical lung biopsy. The HRCT scans were evaluated for AS and IS. The histopathological evaluation comprised myofibroblast foci (MF), intensity of inflammation and fibrosis (Ashcroft score)and numbers of eosinophils and granulomas. For immunohistochemical evaluation primary antibodies against PAR-2, CD124, TGF beta, YY-1 and TSLP were used. The IL-4 and IL-4 R alpha gene polymorphisms were characterized. Results: We found a correlation between eosinophils in lung biopsies and AS. The Ashcroft score was higher in IL-4 HA 2 GCC and MF were more frequent in IL-4 HA 2 TCC carriers. A relationship was found between IL-4 (-1098) A2 T and PAR-2 expression and IL-4 (-590) A1 T, I

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Human immunology

ISSN

0198-8859

e-ISSN

—

Svazek periodika

74

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1346-1351

Kód UT WoS článku

000324789000018

EID výsledku v databázi Scopus

—