Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058760" target="_blank" >RIV/00023001:_____/13:00058760 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S2213177913001248/1-s2.0-S2213177913001248-main.pdf?_tid=94441636-8296-11e3-82e8-00000aab0f27&acdnat=1390307079_ed84d8efc224ca7767fd08705272bd65" target="_blank" >http://ac.els-cdn.com/S2213177913001248/1-s2.0-S2213177913001248-main.pdf?_tid=94441636-8296-11e3-82e8-00000aab0f27&acdnat=1390307079_ed84d8efc224ca7767fd08705272bd65</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jchf.2013.03.008" target="_blank" >10.1016/j.jchf.2013.03.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact

Popis výsledku v původním jazyce

Objectives: The purpose of this study was to compare the prognostic impact of clinical and biomarker correlates of resting heart rate (HR) and chronotropic incompetence in heart failure (HF) patients. Background: The mechanisms and underlying pathophysiological influences of HR abnormalities in HF are incompletely understood. Methods: In a prospective pilot study, 81 patients with advanced systolic HF (97% were receiving beta-blockers) and 25 age-, sex-, and body-size matched healthy controls underwentmaximal cardiopulmonary exercise testing with sampling of neurohormones and biomarkers. Results: Two-thirds of HF patients met criteria for chronotropic incompetence. Resting HR and HR reserve (HRR, a measure of chronotropic response) were not correlatedwith each other and were associated with distinct biomarker profiles. Resting HR correlated with increased myocardial stress (B-type natriuretic peptide [BNP]: r 1/4 0.26; pro A-type natriuretic peptide: r 1/4 0.24; N-terminal(NT)-proBNP

Název v anglickém jazyce

Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact

Popis výsledku anglicky

Objectives: The purpose of this study was to compare the prognostic impact of clinical and biomarker correlates of resting heart rate (HR) and chronotropic incompetence in heart failure (HF) patients. Background: The mechanisms and underlying pathophysiological influences of HR abnormalities in HF are incompletely understood. Methods: In a prospective pilot study, 81 patients with advanced systolic HF (97% were receiving beta-blockers) and 25 age-, sex-, and body-size matched healthy controls underwentmaximal cardiopulmonary exercise testing with sampling of neurohormones and biomarkers. Results: Two-thirds of HF patients met criteria for chronotropic incompetence. Resting HR and HR reserve (HRR, a measure of chronotropic response) were not correlatedwith each other and were associated with distinct biomarker profiles. Resting HR correlated with increased myocardial stress (B-type natriuretic peptide [BNP]: r 1/4 0.26; pro A-type natriuretic peptide: r 1/4 0.24; N-terminal(NT)-proBNP

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/LH12052" target="_blank" >LH12052: Časná detekce a stanovení prognózy srdečního selhání za použití dynamických stanovení biomarkerů poškození myokardu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American college of cardiology : Heart failure

ISSN

2213-1779

e-ISSN

—

Svazek periodika

1

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

259-266

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—