A novel biomarker-based approach for the detection of asymptomatic brain injury during catheter ablation of atrial fibrillation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00058895" target="_blank" >RIV/00023001:_____/14:00058895 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023884:_____/14:#0007185
Výsledek na webu
<a href="http://onlinelibrary.wiley.com/doi/10.1111/jce.12325/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jce.12325/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jce.12325" target="_blank" >10.1111/jce.12325</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A novel biomarker-based approach for the detection of asymptomatic brain injury during catheter ablation of atrial fibrillation
Popis výsledku v původním jazyce
BACKGROUND: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a widely used method for studying of asymptomatic brain injury during catheter ablation of atrial fibrillation (AF). However, this technique lacks sensitivity for subtle or diffuse brain lesions. We investigated whether detection of the ablation-related brain injury can improve by assessment of a biomarker of brain damage-protein S100B. METHODS AND RESULTS: DW-MRI and assessment of S100B were performed in 58 patients undergoing radiofrequency catheter ablation of paroxysmal or persistent AF 1 day before and after the procedure. We observed no symptomatic neurological complications. S100B levels increased after ablation above the upper reference limit of 105 ng/L in 3 patients. One ofthem developed a new ischemic lesion on the DW-MRI. No acute lesions emerged on DW-MRI in the patients with normal postablation S100B levels. CONCLUSION: Serial assessment of serum protein S100B may improve detection of asymptomatic acut
Název v anglickém jazyce
A novel biomarker-based approach for the detection of asymptomatic brain injury during catheter ablation of atrial fibrillation
Popis výsledku anglicky
BACKGROUND: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a widely used method for studying of asymptomatic brain injury during catheter ablation of atrial fibrillation (AF). However, this technique lacks sensitivity for subtle or diffuse brain lesions. We investigated whether detection of the ablation-related brain injury can improve by assessment of a biomarker of brain damage-protein S100B. METHODS AND RESULTS: DW-MRI and assessment of S100B were performed in 58 patients undergoing radiofrequency catheter ablation of paroxysmal or persistent AF 1 day before and after the procedure. We observed no symptomatic neurological complications. S100B levels increased after ablation above the upper reference limit of 105 ng/L in 3 patients. One ofthem developed a new ischemic lesion on the DW-MRI. No acute lesions emerged on DW-MRI in the patients with normal postablation S100B levels. CONCLUSION: Serial assessment of serum protein S100B may improve detection of asymptomatic acut
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of cardiovascular electrophysiology
ISSN
1045-3873
e-ISSN
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Svazek periodika
25
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
349-354
Kód UT WoS článku
000334165500003
EID výsledku v databázi Scopus
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