Effect of mesenchymal stem cells on the vascularization of the artificial site for islet transplantation in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059052" target="_blank" >RIV/00023001:_____/14:00059052 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0041134514004229/1-s2.0-S0041134514004229-main.pdf?_tid=db6d8b4c-7afb-11e4-a964-00000aab0f01&acdnat=1417618466_18a4388270fd46d455c72a257e4de19c" target="_blank" >http://ac.els-cdn.com/S0041134514004229/1-s2.0-S0041134514004229-main.pdf?_tid=db6d8b4c-7afb-11e4-a964-00000aab0f01&acdnat=1417618466_18a4388270fd46d455c72a257e4de19c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2014.05.074" target="_blank" >10.1016/j.transproceed.2014.05.074</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of mesenchymal stem cells on the vascularization of the artificial site for islet transplantation in rats

Popis výsledku v původním jazyce

An adequate vascularization of the artificially created cavity is crucial for subsequent transplantation of isolated pancreatic islets. In a reported study, dynamic contrast-enhanced magnetic resonance imaging was used to assess the effect of mesenchymalstem cells on neoangiogenesis within connective tissue surrounding an implantable biocompatible device. The signal increase detected after injection of magnetic resonance contrast agent in each target region was considered to be an effect of contrast agent, which was related to the blood supply. To minimize the influence of variability in contrast agent application, all outcomes measured in the implanted devices were normalized to the signal intensity of kidney tissue. When supported by mesenchymal stem cells, the mean signal increase intra-abdominally was 42%, 41%, and 64% and within subcutaneously implanted devices was 23%, 54%, and 52% of that measured in kidney.

Název v anglickém jazyce

Effect of mesenchymal stem cells on the vascularization of the artificial site for islet transplantation in rats

Popis výsledku anglicky

An adequate vascularization of the artificially created cavity is crucial for subsequent transplantation of isolated pancreatic islets. In a reported study, dynamic contrast-enhanced magnetic resonance imaging was used to assess the effect of mesenchymalstem cells on neoangiogenesis within connective tissue surrounding an implantable biocompatible device. The signal increase detected after injection of magnetic resonance contrast agent in each target region was considered to be an effect of contrast agent, which was related to the blood supply. To minimize the influence of variability in contrast agent application, all outcomes measured in the implanted devices were normalized to the signal intensity of kidney tissue. When supported by mesenchymal stem cells, the mean signal increase intra-abdominally was 42%, 41%, and 64% and within subcutaneously implanted devices was 23%, 54%, and 52% of that measured in kidney.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

1963-1966

Kód UT WoS článku

000341076800078

EID výsledku v databázi Scopus

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