The HLA-net GENE[RATE] pipeline for effective HLA data analysis and its application to 145 population samples from Europe and neighbouring areas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059159" target="_blank" >RIV/00023001:_____/14:00059159 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/tan.12356/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tan.12356/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tan.12356" target="_blank" >10.1111/tan.12356</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The HLA-net GENE[RATE] pipeline for effective HLA data analysis and its application to 145 population samples from Europe and neighbouring areas

Popis výsledku v původním jazyce

In this review, we present for the first time an integrated version of the GENE[RATE] computer tools which have been developed during the last 5 years to analyse human leukocyte antigen (HLA) data in human populations, as well as the results of their application to a large dataset of 145 HLA-typed population samples from Europe and its two neighbouring areas, North Africa and West Asia, now forming part of the GENE[VA] database. All these computer tools and genetic data are, from now, publicly availablethrough a newly designed bioinformatics platform, HLA-net, here presented as a main achievement of the HLA-NET scientific programme. The GENE[RATE] pipeline offers user-friendly computer tools to estimate allele and haplotype frequencies, to test Hardy-Weinberg equilibrium (HWE), selective neutrality and linkage disequilibrium, to recode HLA data, to convert file formats, to display population frequencies of chosen alleles and haplotypes in selected geographic regions, and to perform ge

Název v anglickém jazyce

The HLA-net GENE[RATE] pipeline for effective HLA data analysis and its application to 145 population samples from Europe and neighbouring areas

Popis výsledku anglicky

In this review, we present for the first time an integrated version of the GENE[RATE] computer tools which have been developed during the last 5 years to analyse human leukocyte antigen (HLA) data in human populations, as well as the results of their application to a large dataset of 145 HLA-typed population samples from Europe and its two neighbouring areas, North Africa and West Asia, now forming part of the GENE[VA] database. All these computer tools and genetic data are, from now, publicly availablethrough a newly designed bioinformatics platform, HLA-net, here presented as a main achievement of the HLA-NET scientific programme. The GENE[RATE] pipeline offers user-friendly computer tools to estimate allele and haplotype frequencies, to test Hardy-Weinberg equilibrium (HWE), selective neutrality and linkage disequilibrium, to recode HLA data, to convert file formats, to display population frequencies of chosen alleles and haplotypes in selected geographic regions, and to perform ge

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tissue Antigens

ISSN

0001-2815

e-ISSN

—

Svazek periodika

83

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

307-323

Kód UT WoS článku

000334356100001

EID výsledku v databázi Scopus

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