White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059254" target="_blank" >RIV/00023001:_____/15:00059254 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985807:_____/15:00441869 RIV/00023752:_____/15:43914680

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0920996415000596#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0920996415000596#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.schres.2015.01.029" target="_blank" >10.1016/j.schres.2015.01.029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Popis výsledku v původním jazyce

Background: White matter abnormality has been recently proposed as a pathophysiological feature of schizophrenia (SZ). However, most of the data available has been gathered from chronic patients, and was therefore possibly confounded by factors such as duration of the disease, and treatment received. The extent and localization of these changes is also not clear. Methods: We examined a population of early stage SZ patients using diffusion tensor imaging (DTI). 77 SZ patients and 60 healthy controls (HCs) were included in the analysis using Tract-Based Spatial Statistics (TBSS). We have also analyzed 250 randomly created subsets of the original cohort, to investigate the relation between the result of TBSS analysis, and the size of the sample studied. Results: We have found a significant decrease in fractional anisotropy (FA) in the patient group. This change is present inmost major white matter (WM) tracts including the corpus callosum, superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculus, and posterior thalamic radiation. Furthermore, we identified a clear trend towards an increase in the number and spatial extent of significant voxels reported, with an increasing number of subjects included in the analysis. Conclusion: Our study shows that FA is significantly decreased in patients at an early stage of schizophrenia, and that the extent of this finding is dependent on the size of studied sample; therefore underpowered studies might produce results with false spatial localization.

Název v anglickém jazyce

White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Popis výsledku anglicky

Background: White matter abnormality has been recently proposed as a pathophysiological feature of schizophrenia (SZ). However, most of the data available has been gathered from chronic patients, and was therefore possibly confounded by factors such as duration of the disease, and treatment received. The extent and localization of these changes is also not clear. Methods: We examined a population of early stage SZ patients using diffusion tensor imaging (DTI). 77 SZ patients and 60 healthy controls (HCs) were included in the analysis using Tract-Based Spatial Statistics (TBSS). We have also analyzed 250 randomly created subsets of the original cohort, to investigate the relation between the result of TBSS analysis, and the size of the sample studied. Results: We have found a significant decrease in fractional anisotropy (FA) in the patient group. This change is present inmost major white matter (WM) tracts including the corpus callosum, superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculus, and posterior thalamic radiation. Furthermore, we identified a clear trend towards an increase in the number and spatial extent of significant voxels reported, with an increasing number of subjects included in the analysis. Conclusion: Our study shows that FA is significantly decreased in patients at an early stage of schizophrenia, and that the extent of this finding is dependent on the size of studied sample; therefore underpowered studies might produce results with false spatial localization.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-23940S" target="_blank" >GA13-23940S: Osobnost a spontánní mozková aktivita během klidu a sledování filmu: vzájemný vztah a strukturní determinanty</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Schizophrenia research

ISSN

0920-9964

e-ISSN

—

Svazek periodika

162

Číslo periodika v rámci svazku

1-3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

22-28

Kód UT WoS článku

000349966400004

EID výsledku v databázi Scopus

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