Ezetimibe added to statin therapy after acute coronary syndromes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059607" target="_blank" >RIV/00023001:_____/15:00059607 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064173:_____/15:N0000011
Výsledek na webu
<a href="http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489" target="_blank" >http://www.nejm.org/doi/pdf/10.1056/NEJMoa1410489</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1056/NEJMoa1410489" target="_blank" >10.1056/NEJMoa1410489</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Ezetimibe added to statin therapy after acute coronary syndromes
Popis výsledku v původním jazyce
BACKGROUND Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (}= 30 days after randomization), or nonfatal stroke. The median follow-up was 6 years. CONCLUSIONS When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit.
Název v anglickém jazyce
Ezetimibe added to statin therapy after acute coronary syndromes
Popis výsledku anglicky
BACKGROUND Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (}= 30 days after randomization), or nonfatal stroke. The median follow-up was 6 years. CONCLUSIONS When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
New England journal of medicine
ISSN
0028-4793
e-ISSN
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Svazek periodika
372
Číslo periodika v rámci svazku
25
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
2387-2397
Kód UT WoS článku
000356354600005
EID výsledku v databázi Scopus
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