Enhanced pulmonary vasodilator reserve and abnormal right ventricular pulmonary artery coupling in heart failure with preserved ejection fraction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059621" target="_blank" >RIV/00023001:_____/15:00059621 - isvavai.cz</a>

Výsledek na webu

<a href="http://circheartfailure.ahajournals.org/content/8/3/542.full.pdf+html" target="_blank" >http://circheartfailure.ahajournals.org/content/8/3/542.full.pdf+html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.002114" target="_blank" >10.1161/CIRCHEARTFAILURE.114.002114</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhanced pulmonary vasodilator reserve and abnormal right ventricular pulmonary artery coupling in heart failure with preserved ejection fraction

Popis výsledku v původním jazyce

Background Pulmonary hypertension and right ventricular (RV) dysfunction are common in patients with advanced heart failure with preserved ejection fraction (HFpEF), yet their underlying mechanisms remain poorly understood. We sought to examine RV-pulmonary artery (PA) functional reserve responses and RV-PA coupling at rest and during -adrenergic stimulation in subjects with earlier stage HFpEF. Conclusions Pulmonary hypertension in early stage HFpEF is related to partially reversible pulmonary vasoconstriction coupled with RV systolic and diastolic dysfunction, even in the absence of RV structural remodeling. Pulmonary vascular tone is more favorably responsive to -adrenergic stimulation in HFpEF than controls, suggesting a potential role for -agonists in the treatment of patients with HFpEF and pulmonary hypertension. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01418248.

Název v anglickém jazyce

Enhanced pulmonary vasodilator reserve and abnormal right ventricular pulmonary artery coupling in heart failure with preserved ejection fraction

Popis výsledku anglicky

Background Pulmonary hypertension and right ventricular (RV) dysfunction are common in patients with advanced heart failure with preserved ejection fraction (HFpEF), yet their underlying mechanisms remain poorly understood. We sought to examine RV-pulmonary artery (PA) functional reserve responses and RV-PA coupling at rest and during -adrenergic stimulation in subjects with earlier stage HFpEF. Conclusions Pulmonary hypertension in early stage HFpEF is related to partially reversible pulmonary vasoconstriction coupled with RV systolic and diastolic dysfunction, even in the absence of RV structural remodeling. Pulmonary vascular tone is more favorably responsive to -adrenergic stimulation in HFpEF than controls, suggesting a potential role for -agonists in the treatment of patients with HFpEF and pulmonary hypertension. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01418248.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Circulation heart failure

ISSN

1941-3289

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

542-550

Kód UT WoS článku

000357079700019

EID výsledku v databázi Scopus

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