VT recurrence after ablation: incomplete ablation or disease progression? A multicentric European study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059757" target="_blank" >RIV/00023001:_____/16:00059757 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/jce.12858" target="_blank" >http://dx.doi.org/10.1111/jce.12858</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jce.12858" target="_blank" >10.1111/jce.12858</a>

Jazyk výsledku

angličtina

Název v původním jazyce

VT recurrence after ablation: incomplete ablation or disease progression? A multicentric European study

Popis výsledku v původním jazyce

NICM VT Ablation AimTo determine whether ventricular tachycardia (VT) recurrences in arrhythmogenic RV cardiomyopathy (ARVC) and nonischemic cardiomyopathy (NICM) are related to incomplete ablation or disease progression. MethodsARVC and NICM patients with two substrate maps of the same diseased ventricle with an interprocedural delay of 12 months were included. Disease progression was defined as 1 factor: scar area progression (PROG, +5%), ventricular remodeling (dilatation [+25 mL] or decreased ejection fraction [-5%EF]). Incomplete ablation was defined as index VT recurrence or ablation in previously unablated regions inside index scar without PROG. ResultsTwenty patients from nine centers were included (80% male 55 16years, 7 ARVC and 13 NICM, LVEF 43 +/- 14%). Mean delay was 28 +/- 18 months. Disease progression occurred in 75% with ventricular remodeling in 70%: ventricular dilation in 45% (ARVC [71%]; NICM [38%]), decreased EF in 60% [RVEF in ARVC (71%); LVEF in NICM (54%)], and scar progression in 50% (in ARVC [57%] and NICM [46%]). Index VT recurrence was observed in 40%. Redo ablation sites were located in previously unablated regions inside the index scar in 70% of patients. VT recurrence following the second procedure was seen in 25%. Fifteen percent died during a follow-up of 17 +/- 17 months. ConclusionDisease progression is the rule in ARVC and NICM while scar progression occurs in half. However, even if disease progression is frequently observed, incomplete index ablation is the most common finding, strongly suggesting the need for more extensive ablation.

Název v anglickém jazyce

VT recurrence after ablation: incomplete ablation or disease progression? A multicentric European study

Popis výsledku anglicky

NICM VT Ablation AimTo determine whether ventricular tachycardia (VT) recurrences in arrhythmogenic RV cardiomyopathy (ARVC) and nonischemic cardiomyopathy (NICM) are related to incomplete ablation or disease progression. MethodsARVC and NICM patients with two substrate maps of the same diseased ventricle with an interprocedural delay of 12 months were included. Disease progression was defined as 1 factor: scar area progression (PROG, +5%), ventricular remodeling (dilatation [+25 mL] or decreased ejection fraction [-5%EF]). Incomplete ablation was defined as index VT recurrence or ablation in previously unablated regions inside index scar without PROG. ResultsTwenty patients from nine centers were included (80% male 55 16years, 7 ARVC and 13 NICM, LVEF 43 +/- 14%). Mean delay was 28 +/- 18 months. Disease progression occurred in 75% with ventricular remodeling in 70%: ventricular dilation in 45% (ARVC [71%]; NICM [38%]), decreased EF in 60% [RVEF in ARVC (71%); LVEF in NICM (54%)], and scar progression in 50% (in ARVC [57%] and NICM [46%]). Index VT recurrence was observed in 40%. Redo ablation sites were located in previously unablated regions inside the index scar in 70% of patients. VT recurrence following the second procedure was seen in 25%. Fifteen percent died during a follow-up of 17 +/- 17 months. ConclusionDisease progression is the rule in ARVC and NICM while scar progression occurs in half. However, even if disease progression is frequently observed, incomplete index ablation is the most common finding, strongly suggesting the need for more extensive ablation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of cardiovascular electrophysiology

ISSN

1045-3873

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

80-87

Kód UT WoS článku

000368017000011

EID výsledku v databázi Scopus

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