Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059792" target="_blank" >RIV/00023001:_____/16:00059792 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10322886 RIV/00064165:_____/16:10322886

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0009898116300055" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0009898116300055</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2016.01.005" target="_blank" >10.1016/j.cca.2016.01.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

Popis výsledku v původním jazyce

Aim: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (<50 years) and older CVD patients. Methods: 1191 controls and 1889 MI patients were analyzed. All participants were Caucasian Czech males aged <65 years (532 were <50 years) who were examined at cardiology clinics in Prague, Czech Republic. Variants of FTO, 9p21, 2q36.3, and KIF-6 were genotyped using PCR-RFLP or TaqMan assay. Results: Variants of FTO (OR 1.48; 95% CI, 1.19-1.84 in a TT vs. GG comparison, p = 0.0005); 9p21 (OR 1.74; 95% CI, 1.41-2.14 in an AA vs. GG comparison, p = 0.0001); and 2836.3 (OR 134; 95%Cl, 1.09-1.65 in an AA vs. +C comparison, p = 0.006) were significantly associated with MI in the male Czech population. In contrast, genotype frequencies of KIF-6 (rs20455) were the same in patients and controls (P = 1.00). Nearly identical results were observed when a subset of young MI patients (N = 532, aged <50 years) was analyzed. Conclusion: We confirmed the importance of determining FTO, 9p21, and 2q36.3 variants as part of the genetic determination of MI risk in the Czech male population.

Název v anglickém jazyce

Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

Popis výsledku anglicky

Aim: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (<50 years) and older CVD patients. Methods: 1191 controls and 1889 MI patients were analyzed. All participants were Caucasian Czech males aged <65 years (532 were <50 years) who were examined at cardiology clinics in Prague, Czech Republic. Variants of FTO, 9p21, 2q36.3, and KIF-6 were genotyped using PCR-RFLP or TaqMan assay. Results: Variants of FTO (OR 1.48; 95% CI, 1.19-1.84 in a TT vs. GG comparison, p = 0.0005); 9p21 (OR 1.74; 95% CI, 1.41-2.14 in an AA vs. GG comparison, p = 0.0001); and 2836.3 (OR 134; 95%Cl, 1.09-1.65 in an AA vs. +C comparison, p = 0.006) were significantly associated with MI in the male Czech population. In contrast, genotype frequencies of KIF-6 (rs20455) were the same in patients and controls (P = 1.00). Nearly identical results were observed when a subset of young MI patients (N = 532, aged <50 years) was analyzed. Conclusion: We confirmed the importance of determining FTO, 9p21, and 2q36.3 variants as part of the genetic determination of MI risk in the Czech male population.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12217" target="_blank" >NT12217: Genetické faktory určující riziko aterotrombotických cévních příhod u nemocných bez klasických rizikových faktorů aterosklerózy a u pacientů léčených statinem</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinica chimica acta

ISSN

0009-8981

e-ISSN

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Svazek periodika

454

Číslo periodika v rámci svazku

February 15

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

119-123

Kód UT WoS článku

000370305800022

EID výsledku v databázi Scopus

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