Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059823" target="_blank" >RIV/00023001:_____/16:00059823 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S000989811530111X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S000989811530111X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2015.12.041" target="_blank" >10.1016/j.cca.2015.12.041</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women

Popis výsledku v původním jazyce

The association between leukocyte telomere length (LTL) and cardiovascular disease (CVD) has been published in many reports, although almost exclusively in men. In our study we analysed the association between LTL and five selected variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and rs8053257; UCP2 rs659366 and rs622064), which are not only involved in telomere-length maintenance but also potentially associated with higher risk of acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls). We detected significantly shorter LTL in women with ACS (P < 0.001), but the difference disappeared after multiple adjustments. We did not find any significant associations between analysed variants and LTL, except for rs622064 within the UCP2 gene, in which case AA homozygotes had a higher LTL (P < 0.04). Genotype frequencies of the analysed SNP5 did not differ between controls and women with ACS. Variants within UCP2 (rs622064; CC vs. A allele carriers OR = 1.61; 95% CI: 121-2.15, P < 0.002) and within TERF2IP (rs8053257; A allele carriers vs. GG, OR = 1.78; 95% CI: 1.07-3.18, P < 0.03) were associated with increased risk of type 2 diabetes mellitus (T2DM). Analysed polymorphisms were not major determinants of telomere length or ACS risk in Czech females.

Název v anglickém jazyce

Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women

Popis výsledku anglicky

The association between leukocyte telomere length (LTL) and cardiovascular disease (CVD) has been published in many reports, although almost exclusively in men. In our study we analysed the association between LTL and five selected variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and rs8053257; UCP2 rs659366 and rs622064), which are not only involved in telomere-length maintenance but also potentially associated with higher risk of acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls). We detected significantly shorter LTL in women with ACS (P < 0.001), but the difference disappeared after multiple adjustments. We did not find any significant associations between analysed variants and LTL, except for rs622064 within the UCP2 gene, in which case AA homozygotes had a higher LTL (P < 0.04). Genotype frequencies of the analysed SNP5 did not differ between controls and women with ACS. Variants within UCP2 (rs622064; CC vs. A allele carriers OR = 1.61; 95% CI: 121-2.15, P < 0.002) and within TERF2IP (rs8053257; A allele carriers vs. GG, OR = 1.78; 95% CI: 1.07-3.18, P < 0.03) were associated with increased risk of type 2 diabetes mellitus (T2DM). Analysed polymorphisms were not major determinants of telomere length or ACS risk in Czech females.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14008" target="_blank" >NT14008: Vliv menopauzy na rozvoj kardiometabolického rizika a známek postižení cévní stěny – dlouhodobá longitudinální studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinica chimica acta

ISSN

0009-8981

e-ISSN

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Svazek periodika

454

Číslo periodika v rámci svazku

February 15

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

62-65

Kód UT WoS článku

000370305800012

EID výsledku v databázi Scopus

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