Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060011" target="_blank" >RIV/00023001:_____/16:00060011 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0378111916306163/1-s2.0-S0378111916306163-main.pdf?_tid=66e0d1cc-96c8-11e6-9e96-00000aab0f26&acdnat=1476969994_67b520003b2173d767172c1dfa7b54a2" target="_blank" >http://ac.els-cdn.com/S0378111916306163/1-s2.0-S0378111916306163-main.pdf?_tid=66e0d1cc-96c8-11e6-9e96-00000aab0f26&acdnat=1476969994_67b520003b2173d767172c1dfa7b54a2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gene.2016.07.070" target="_blank" >10.1016/j.gene.2016.07.070</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology

Popis výsledku v původním jazyce

Apolipoprotein A5 (APOA5) is a small protein, expressed predominantly in the liver. In plasma, it is located on triglyceride rich lipoprotein particles (chylomicrones and VLDL) and on HDL Plasma concentration of apolipoprotein A5 is very low, suggesting rather regulatory (activation of lipoprotein lipase, ... ) than structural function. APOA5 is an important determinant of plasma triglyceride concentration; this effect has been confirmed both on animal models, as well as on human studies. Minor alleles of three commonly analysed variants within this gene (rs662799, rs3135506, rs2075291) are associated with higher plasma TG values and increased risk of myocardial infarction, with some important interethnic differences observed. Further roles of APOA5; determination of BMI, diabetes and last but not least nutri- and pharmaco-genetic interactions are suggested, but without the definitive conclusions.

Název v anglickém jazyce

Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology

Popis výsledku anglicky

Apolipoprotein A5 (APOA5) is a small protein, expressed predominantly in the liver. In plasma, it is located on triglyceride rich lipoprotein particles (chylomicrones and VLDL) and on HDL Plasma concentration of apolipoprotein A5 is very low, suggesting rather regulatory (activation of lipoprotein lipase, ... ) than structural function. APOA5 is an important determinant of plasma triglyceride concentration; this effect has been confirmed both on animal models, as well as on human studies. Minor alleles of three commonly analysed variants within this gene (rs662799, rs3135506, rs2075291) are associated with higher plasma TG values and increased risk of myocardial infarction, with some important interethnic differences observed. Further roles of APOA5; determination of BMI, diabetes and last but not least nutri- and pharmaco-genetic interactions are suggested, but without the definitive conclusions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gene

ISSN

0378-1119

e-ISSN

—

Svazek periodika

592

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

193-199

Kód UT WoS článku

000383304600025

EID výsledku v databázi Scopus

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