Interlobular arteries from 2-kidney, 1-clip goldblatt hypertensive rats' exhibit-impaired vasodilator response to epoxyeicosatrienoic acids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060012" target="_blank" >RIV/00023001:_____/16:00060012 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10327949

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0002962916002056" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0002962916002056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amjms.2016.02.030" target="_blank" >10.1016/j.amjms.2016.02.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interlobular arteries from 2-kidney, 1-clip goldblatt hypertensive rats' exhibit-impaired vasodilator response to epoxyeicosatrienoic acids

Popis výsledku v původním jazyce

Background: Small renal arteries have a significant role in the regulation of renal hemodynamics and blood pressure (BP). To study potential changes in the regulation of vascular function in hypertension, we examined renal vasodilatory responses of small arteries from nonclipped kidneys of the 2-kidney, 1-clip Goldblatt hypertensive rats to native epoxyeicosatrienoic acids (EETs) that are believed to be involved in the regulation of renal vascular function and BP. A total of 2 newly synthesized EET analogues were also examined. Materials and Methods: Renal interlobular arteries isolated from the nonclipped kidneys on day 28 after clipping were preconstricted with phenylephrine, pressurized and the effects of a 14,15-EET analogue, native 14,15-EET and 11,12-ether-EET-8ZE, an analogue of 11,12-EET, on the vascular diameter were determined and compared to the responses of arteries from the kidneys of sham-operated rats. Results: In the arteries from nonclipped kidneys isolated in the maintenance phase of Goldblatt hypertension, the maximal vasodilatory response to 14,15-EET analogue was 30.1 +/- 2.8% versus 49.8 +/- 7.2% in sham-operated rats; the respective values for 11,12-ther-EET-8ZE were 31.4 +/- 6.4% versus 80.4 +/- 6%, and for native EETs they were 41.7 +/- 6.6% versus 62.8 +/- 4.4% (P = 0.05 for each difference). Conclusions: We propose that reduced vasodilatory action and decreased intrarenal bioavailability of EETs combined with intrarenal angiotensin II levels that are inappropriately high for hypertensive rats underlie functional derangements of the nonclipped kidneys of 2-kidney, 1-clip Goldblatt hypertensive rats. These derangements could play an important role in pathophysiology of sustained BP elevation observed in this animal model of human renovascular hypertension.

Název v anglickém jazyce

Interlobular arteries from 2-kidney, 1-clip goldblatt hypertensive rats' exhibit-impaired vasodilator response to epoxyeicosatrienoic acids

Popis výsledku anglicky

Background: Small renal arteries have a significant role in the regulation of renal hemodynamics and blood pressure (BP). To study potential changes in the regulation of vascular function in hypertension, we examined renal vasodilatory responses of small arteries from nonclipped kidneys of the 2-kidney, 1-clip Goldblatt hypertensive rats to native epoxyeicosatrienoic acids (EETs) that are believed to be involved in the regulation of renal vascular function and BP. A total of 2 newly synthesized EET analogues were also examined. Materials and Methods: Renal interlobular arteries isolated from the nonclipped kidneys on day 28 after clipping were preconstricted with phenylephrine, pressurized and the effects of a 14,15-EET analogue, native 14,15-EET and 11,12-ether-EET-8ZE, an analogue of 11,12-EET, on the vascular diameter were determined and compared to the responses of arteries from the kidneys of sham-operated rats. Results: In the arteries from nonclipped kidneys isolated in the maintenance phase of Goldblatt hypertension, the maximal vasodilatory response to 14,15-EET analogue was 30.1 +/- 2.8% versus 49.8 +/- 7.2% in sham-operated rats; the respective values for 11,12-ther-EET-8ZE were 31.4 +/- 6.4% versus 80.4 +/- 6%, and for native EETs they were 41.7 +/- 6.6% versus 62.8 +/- 4.4% (P = 0.05 for each difference). Conclusions: We propose that reduced vasodilatory action and decreased intrarenal bioavailability of EETs combined with intrarenal angiotensin II levels that are inappropriately high for hypertensive rats underlie functional derangements of the nonclipped kidneys of 2-kidney, 1-clip Goldblatt hypertensive rats. These derangements could play an important role in pathophysiology of sustained BP elevation observed in this animal model of human renovascular hypertension.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14011" target="_blank" >NT14011: Vliv genové inaktivace B2 receptorů pro bradykinin v distálním tubulu myši na transport sodíku u experimentálních modelů hypertenze</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of the medical sciences

ISSN

0002-9629

e-ISSN

—

Svazek periodika

351

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

513-519

Kód UT WoS článku

000382666100013

EID výsledku v databázi Scopus

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