Altered neural correlate of the self-agency experience in first-episode schizophrenia-spectrum patients: an fMRI study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060072" target="_blank" >RIV/00023001:_____/16:00060072 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00090378 RIV/00216208:11120/16:43910991 RIV/65269705:_____/16:00066112 RIV/00023752:_____/16:43914876

Výsledek na webu

<a href="https://academic.oup.com/schizophreniabulletin/article-abstract/42/4/916/2413876/Altered-Neural-Correlate-of-the-Self-Agency?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/schizophreniabulletin/article-abstract/42/4/916/2413876/Altered-Neural-Correlate-of-the-Self-Agency?redirectedFrom=fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/schbul/sbv188" target="_blank" >10.1093/schbul/sbv188</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered neural correlate of the self-agency experience in first-episode schizophrenia-spectrum patients: an fMRI study

Popis výsledku v původním jazyce

Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P <.05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Název v anglickém jazyce

Altered neural correlate of the self-agency experience in first-episode schizophrenia-spectrum patients: an fMRI study

Popis výsledku anglicky

Background: The phenomenology of the clinical symptoms indicates that disturbance of the sense of self be a core marker of schizophrenia. Aims: To compare neural activity related to the self/other-agency judgment in patients with first-episode schizophrenia-spectrum disorders (FES, n = 35) and healthy controls (HC, n = 35). Method: A functional magnetic resonance imaging (fMRI) using motor task with temporal distortion of the visual feedback was employed. A task-related functional connectivity was analyzed with the use of independent component analysis (ICA). Results: (1) During self-agency experience, FES showed a deficit in cortical activation in medial frontal gyrus (BA 10) and posterior cingulate gyrus, (BA 31; P <.05, Family-Wise Error [FWE] corrected). (2) Pooled-sample task-related ICA revealed that the self/other-agency judgment was dependent upon anti-correlated default mode and central-executive networks (DMN/CEN) dynamic switching. This antagonistic mechanism was substantially impaired in FES during the task. Discussion: During self-agency experience, FES demonstrate deficit in engagement of cortical midline structures along with substantial attenuation of anti-correlated DMN/CEN activity underlying normal self/other-agency discriminative processes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14291" target="_blank" >NT14291: Regionální strukturální, funkční a spektroskopické změny v oblasti insuly u časných epizod psychotického onemocnění.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Schizophrenia bulletin

ISSN

0586-7614

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

916-925

Kód UT WoS článku

000385280800013

EID výsledku v databázi Scopus

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