Sequential hybrid CryoMaze ablation versus surgical CryoMaze alone for the treatment of atrial fibrillation (SurHyb): study protocol for a randomized controlled trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060081" target="_blank" >RIV/00023001:_____/16:00060081 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12110/16:43891903 RIV/00216224:14110/16:00092164 RIV/00023884:_____/16:#0007153

Výsledek na webu

<a href="http://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1634-4" target="_blank" >http://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1634-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13063-016-1634-4" target="_blank" >10.1186/s13063-016-1634-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sequential hybrid CryoMaze ablation versus surgical CryoMaze alone for the treatment of atrial fibrillation (SurHyb): study protocol for a randomized controlled trial

Popis výsledku v původním jazyce

Background: Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment in several trials, but success rates have varied considerably, between 47-95 %. The sequential hybrid approach, combining surgical CryoMaze followed by radiofrequency catheter ablation, can achieve high freedom from atrial arrhythmias, even when rigorous methods to detect arrhythmias after the procedure are used. However, data from randomized trials comparing hybrid ablations to surgical ablations alone are lacking. Methods/Design: The SurHyb study is a prospective, multicenter, randomized study. Patients with persistent or long-standing persistent atrial fibrillation will be randomized to either surgical CryoMaze alone or surgical CryoMaze followed by catheter ablation 3 months post-surgery. The primary outcome measure is arrhythmia-free survival without class I or III antiarrhythmic drugs, which will be evaluated using 7-day ECG Holter monitoring at 24 months. A total of 260 patients will be investigated from three medical centers in the Czech Republic to obtain the relevant information. Discussion: This is the first randomized study that compares surgical CryoMaze alone with the staged hybrid surgical CryoMaze followed by catheter ablation in patients with persistent or long-standing persistent atrial fibrillation. These results will contribute to the optimization of the treatment for these patients.

Název v anglickém jazyce

Sequential hybrid CryoMaze ablation versus surgical CryoMaze alone for the treatment of atrial fibrillation (SurHyb): study protocol for a randomized controlled trial

Popis výsledku anglicky

Background: Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment in several trials, but success rates have varied considerably, between 47-95 %. The sequential hybrid approach, combining surgical CryoMaze followed by radiofrequency catheter ablation, can achieve high freedom from atrial arrhythmias, even when rigorous methods to detect arrhythmias after the procedure are used. However, data from randomized trials comparing hybrid ablations to surgical ablations alone are lacking. Methods/Design: The SurHyb study is a prospective, multicenter, randomized study. Patients with persistent or long-standing persistent atrial fibrillation will be randomized to either surgical CryoMaze alone or surgical CryoMaze followed by catheter ablation 3 months post-surgery. The primary outcome measure is arrhythmia-free survival without class I or III antiarrhythmic drugs, which will be evaluated using 7-day ECG Holter monitoring at 24 months. A total of 260 patients will be investigated from three medical centers in the Czech Republic to obtain the relevant information. Discussion: This is the first randomized study that compares surgical CryoMaze alone with the staged hybrid surgical CryoMaze followed by catheter ablation in patients with persistent or long-standing persistent atrial fibrillation. These results will contribute to the optimization of the treatment for these patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trials

ISSN

1745-6215

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

October 24

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

"art. no. 518"

Kód UT WoS článku

000386077600003

EID výsledku v databázi Scopus

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