Inhaled sodium nitrite improves rest and exercise hemodynamics in heart failure with preserved ejection fraction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060150" target="_blank" >RIV/00023001:_____/16:00060150 - isvavai.cz</a>

Výsledek na webu

<a href="http://circres.ahajournals.org/content/119/7/880" target="_blank" >http://circres.ahajournals.org/content/119/7/880</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCRESAHA.116.309184" target="_blank" >10.1161/CIRCRESAHA.116.309184</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inhaled sodium nitrite improves rest and exercise hemodynamics in heart failure with preserved ejection fraction

Popis výsledku v původním jazyce

Rationale: Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chronic use. Objective: Determine whether inhaled nitrite improves hemodynamics in HFpEF. Methods and Results: In a double-blind, randomized, placebo-controlled, parallel-group trial, subjects with HFpEF (n=2 (6)) underwent cardiac catheterization with simultaneous expired gas analysis at rest and during exercise before and after treatment with inhaled sodium nitrite (90 mg) or placebo. The primary end point was the pulmonary capillary wedge pressure during exercise. Before study drug administration, HFpEF subjects displayed an increase in pulmonary capillary wedge pressure with exercise from 20 +/- 6 to 34 +/- 7 mm Hg (P<0.0001). After study drug administration, exercise pulmonary capillary wedge pressure was substantially improved by nitrite as compared with placebo (baseline-adjusted mean 25 +/- 5 versus 31 +/- 6 mm Hg; analysis of covariance P=0.022). Inhaled nitrite reduced resting pulmonary capillary wedge pressure (-4 +/- 3 versus -1 +/- 2 mm Hg; P=0.002), improved pulmonary artery compliance (+1.5 +/- 1.1 versus +0.6 +/- 0.9 mL/mm Hg), and decreased mean pulmonary artery pressures at rest (-7 +/- 4 versus -3 +/- 4 mm Hg; P=0.007) and with exercise (-10 +/- 6 versus -5 +/- 6 mm Hg; P=0.05). Nitrite reduced right atrial pressures, with no effect on cardiac output or stroke volume. Conclusions: Acute administration of inhaled sodium nitrite reduces biventricular filling pressures and pulmonary artery pressures at rest and during exercise in HFpEF. Further study is warranted to evaluate chronic effects of inhaled nitrite in HFpEF.

Název v anglickém jazyce

Inhaled sodium nitrite improves rest and exercise hemodynamics in heart failure with preserved ejection fraction

Popis výsledku anglicky

Rationale: Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chronic use. Objective: Determine whether inhaled nitrite improves hemodynamics in HFpEF. Methods and Results: In a double-blind, randomized, placebo-controlled, parallel-group trial, subjects with HFpEF (n=2 (6)) underwent cardiac catheterization with simultaneous expired gas analysis at rest and during exercise before and after treatment with inhaled sodium nitrite (90 mg) or placebo. The primary end point was the pulmonary capillary wedge pressure during exercise. Before study drug administration, HFpEF subjects displayed an increase in pulmonary capillary wedge pressure with exercise from 20 +/- 6 to 34 +/- 7 mm Hg (P<0.0001). After study drug administration, exercise pulmonary capillary wedge pressure was substantially improved by nitrite as compared with placebo (baseline-adjusted mean 25 +/- 5 versus 31 +/- 6 mm Hg; analysis of covariance P=0.022). Inhaled nitrite reduced resting pulmonary capillary wedge pressure (-4 +/- 3 versus -1 +/- 2 mm Hg; P=0.002), improved pulmonary artery compliance (+1.5 +/- 1.1 versus +0.6 +/- 0.9 mL/mm Hg), and decreased mean pulmonary artery pressures at rest (-7 +/- 4 versus -3 +/- 4 mm Hg; P=0.007) and with exercise (-10 +/- 6 versus -5 +/- 6 mm Hg; P=0.05). Nitrite reduced right atrial pressures, with no effect on cardiac output or stroke volume. Conclusions: Acute administration of inhaled sodium nitrite reduces biventricular filling pressures and pulmonary artery pressures at rest and during exercise in HFpEF. Further study is warranted to evaluate chronic effects of inhaled nitrite in HFpEF.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Circulation research

ISSN

0009-7330

e-ISSN

—

Svazek periodika

119

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

880-886

Kód UT WoS článku

000384001200016

EID výsledku v databázi Scopus

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