Complement in kidney transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075893" target="_blank" >RIV/00023001:_____/17:00075893 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3389/fmed.2017.00066" target="_blank" >http://dx.doi.org/10.3389/fmed.2017.00066</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmed.2017.00066" target="_blank" >10.3389/fmed.2017.00066</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Complement in kidney transplantation

Popis výsledku v původním jazyce

The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.

Název v anglickém jazyce

Complement in kidney transplantation

Popis výsledku anglicky

The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/NV15-26865A" target="_blank" >NV15-26865A: Alloreaktivita u transplantací ledvin u žijících dárců</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in medicine [online]

ISSN

2296-858X

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

May 30

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

"art. no. 66"

Kód UT WoS článku

000407114200001

EID výsledku v databázi Scopus

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