Lack of impact of hyperchloremia in brain-dead organ donors on the onset of kidney allograft function in the recipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075956" target="_blank" >RIV/00023001:_____/17:00075956 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/17:E0106486

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0041134517303196?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0041134517303196?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2017.02.053" target="_blank" >10.1016/j.transproceed.2017.02.053</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lack of impact of hyperchloremia in brain-dead organ donors on the onset of kidney allograft function in the recipients

Popis výsledku v původním jazyce

Background. Hyperchloremia produces renal vasoconstriction and fall in glomerular filtration rate. In 90% of brain-dead organ donors, diabetes insipidus develops, characterized by inappropriate diuresis, hyperosmolality, and hyperchloremia. The aim of this study was to determine the relationship between the serum concentration of chlorides of the donor and the onset of the function of the kidney allograft in the recipient. Methods. We retrospectively studied 213 donors and kidney allograft recipients. Serum creatinine concentrations and glomerular filtration rates on the 1st, 7th, and 30th days after transplantation of the recipients from hyperchloremic donors were compared with the recipients from normochloremic donors, as well as the incidences of acute tubular necrosis and delayed graft function. Results. On the 1st day, serum creatinine concentrations of the recipients from hyperchloremic and normochloremic donors, respectively, were 448.2 +/- 212.1 mu mol/L and 502.2 +/- 197.8 mu mol/L (P = .1), on the 7th day, 168.6 +/- 102.6 mu mol/L and 196.9 +/- 120.6 mmol/L (P = .13), and on the 30th day, 129.4 +/- 43.3 mu mol/L and 131.8 43.6 mu mol/L (P = .73). The differences were statistically significant. The groups also did not differ significantly in glomerular filtration rates and incidences of acute tubular necrosis and delayed graft function. Conclusions. In this study, no significant correlation between serum chloride concentrations of the organ donors and the onset of the function of kidney allografts in the recipients was found.

Název v anglickém jazyce

Lack of impact of hyperchloremia in brain-dead organ donors on the onset of kidney allograft function in the recipients

Popis výsledku anglicky

Background. Hyperchloremia produces renal vasoconstriction and fall in glomerular filtration rate. In 90% of brain-dead organ donors, diabetes insipidus develops, characterized by inappropriate diuresis, hyperosmolality, and hyperchloremia. The aim of this study was to determine the relationship between the serum concentration of chlorides of the donor and the onset of the function of the kidney allograft in the recipient. Methods. We retrospectively studied 213 donors and kidney allograft recipients. Serum creatinine concentrations and glomerular filtration rates on the 1st, 7th, and 30th days after transplantation of the recipients from hyperchloremic donors were compared with the recipients from normochloremic donors, as well as the incidences of acute tubular necrosis and delayed graft function. Results. On the 1st day, serum creatinine concentrations of the recipients from hyperchloremic and normochloremic donors, respectively, were 448.2 +/- 212.1 mu mol/L and 502.2 +/- 197.8 mu mol/L (P = .1), on the 7th day, 168.6 +/- 102.6 mu mol/L and 196.9 +/- 120.6 mmol/L (P = .13), and on the 30th day, 129.4 +/- 43.3 mu mol/L and 131.8 43.6 mu mol/L (P = .73). The differences were statistically significant. The groups also did not differ significantly in glomerular filtration rates and incidences of acute tubular necrosis and delayed graft function. Conclusions. In this study, no significant correlation between serum chloride concentrations of the organ donors and the onset of the function of kidney allografts in the recipients was found.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30213 - Transplantation

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation proceedings

ISSN

0041-1345

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1262-1269

Kód UT WoS článku

000406734700010

EID výsledku v databázi Scopus

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