Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00076205" target="_blank" >RIV/00023001:_____/17:00076205 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/17:00067917 RIV/00159816:_____/17:00067917

Výsledek na webu

<a href="https://academic.oup.com/europace/article-abstract/19/11/1781/2952429" target="_blank" >https://academic.oup.com/europace/article-abstract/19/11/1781/2952429</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/europace/euw282" target="_blank" >10.1093/europace/euw282</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation

Popis výsledku v původním jazyce

Aims Identifying patients who benefit from restored sinus rhythm (SR) would optimize the selection of candidates for ablation of long-standing persistent atrial fibrillation (LSPAF). This prospective study sought to identify the hitherto unknown factors associated with global functional improvement after successful radiofrequency catheter ablation of LSPAF. Methods and results In 171 LSPAF patients (84% of the total consecutive 203 patients) who were examined in SR 12 months after ablation, the individual per cent change from baseline value in maximum oxygen consumption at exercise test (VO2 max), left ventricular ejection fraction (LVEF), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and five-dimensional descriptive system (EQ-5D) of quality-of-life questionnaire were classified in quartiles by 0 (worse) to 3 (best) grades. The individual grades were summed into a composite score (SCORE, 0... 12) reflecting global functional improvement. Significant improvement in VO2 max (3.4 +/- 4.7 mL/kg/min), LVEF (7.5 +/- 9.1%), NT-proBNP (-861 +/- 809 pg/mL), and EQ-5D (0.7 +/- 0.12) was observed (all P &lt; 0.0001). On multivariable analysis, younger age (P = 0.001), male gender (P = 0.02), timely post-ablation left atrial appendage (LAA) outflow (P = 0.005) with improvement in outflow velocity (P = 0.0002), and withdrawal of Class I/III antiarrhythmic drugs (P &lt; 0.05) were positively and independently correlated with the SCORE. Conclusions Younger male patients benefited most from catheter ablation of LSPAF. Delayed or non-improved LAA outflow and inability to discontinue Class I/III antiarrhythmic medication reduced the post-ablation functional improvement.

Název v anglickém jazyce

Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation

Popis výsledku anglicky

Aims Identifying patients who benefit from restored sinus rhythm (SR) would optimize the selection of candidates for ablation of long-standing persistent atrial fibrillation (LSPAF). This prospective study sought to identify the hitherto unknown factors associated with global functional improvement after successful radiofrequency catheter ablation of LSPAF. Methods and results In 171 LSPAF patients (84% of the total consecutive 203 patients) who were examined in SR 12 months after ablation, the individual per cent change from baseline value in maximum oxygen consumption at exercise test (VO2 max), left ventricular ejection fraction (LVEF), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and five-dimensional descriptive system (EQ-5D) of quality-of-life questionnaire were classified in quartiles by 0 (worse) to 3 (best) grades. The individual grades were summed into a composite score (SCORE, 0... 12) reflecting global functional improvement. Significant improvement in VO2 max (3.4 +/- 4.7 mL/kg/min), LVEF (7.5 +/- 9.1%), NT-proBNP (-861 +/- 809 pg/mL), and EQ-5D (0.7 +/- 0.12) was observed (all P &lt; 0.0001). On multivariable analysis, younger age (P = 0.001), male gender (P = 0.02), timely post-ablation left atrial appendage (LAA) outflow (P = 0.005) with improvement in outflow velocity (P = 0.0002), and withdrawal of Class I/III antiarrhythmic drugs (P &lt; 0.05) were positively and independently correlated with the SCORE. Conclusions Younger male patients benefited most from catheter ablation of LSPAF. Delayed or non-improved LAA outflow and inability to discontinue Class I/III antiarrhythmic medication reduced the post-ablation functional improvement.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NR9143" target="_blank" >NR9143: Klinický význam přídatných pravosíňových lézí připojených k obkružujícím a lineárním lézím v levé srdeční síni v ablační léčbě chronické fibrilace síní - prospektivní randomizovaná studie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Europace

ISSN

1099-5129

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1781-1789

Kód UT WoS článku

000414367100007

EID výsledku v databázi Scopus

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