Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00076327" target="_blank" >RIV/00023001:_____/17:00076327 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/17:00474727

Výsledek na webu

<a href="https://briefs.techconnect.org/books/biotech-biomaterials-and-biomedical-techconnect-briefs-2017/" target="_blank" >https://briefs.techconnect.org/books/biotech-biomaterials-and-biomedical-techconnect-briefs-2017/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles

Popis výsledku v původním jazyce

We have developed monodisperse magnetic Fe3O4, upconversion NaYF4:Yb3+/Er3+, and dual paramagnetic/upconversion NaGdF4:Yb3+/Er3+ nanoparticles with tunable size by thermal decomposition of Fe(III) oleate and lanthanide chlorides in hight-boiling organic solvents. Aminosilica and 4-pentynoic acid were then introduced on the particle surface to conjugate the cell adhesive and cell penetrating RGD and TAT peptides, respectively. Optionally, NaYF4:Yb3+/Er3+ @SiO2-NH2 particles reacted with methoxyPEG succinimidyl ester to diminish uptake of the particles by the reticulo-endothelial system. Neural stem cell viability and labeling efficiency of the particles were determined. Al carboxyphthalocyanine was conjugated to NaYF4:Yb3+/Er3+@SiO2-PEG nanoparticles, which were intravenously administered in athymic nude mice with xenotransplanated human prostate carcinoma PC-3. After NIR photodynamic therapy, the tumor subsided and its volume approached to zero.

Název v anglickém jazyce

Carcinoma cellular uptake, imaging, and targeting by RGD- and TAT-conjugated upconversion and/or magnetic nanoparticles

Popis výsledku anglicky

We have developed monodisperse magnetic Fe3O4, upconversion NaYF4:Yb3+/Er3+, and dual paramagnetic/upconversion NaGdF4:Yb3+/Er3+ nanoparticles with tunable size by thermal decomposition of Fe(III) oleate and lanthanide chlorides in hight-boiling organic solvents. Aminosilica and 4-pentynoic acid were then introduced on the particle surface to conjugate the cell adhesive and cell penetrating RGD and TAT peptides, respectively. Optionally, NaYF4:Yb3+/Er3+ @SiO2-NH2 particles reacted with methoxyPEG succinimidyl ester to diminish uptake of the particles by the reticulo-endothelial system. Neural stem cell viability and labeling efficiency of the particles were determined. Al carboxyphthalocyanine was conjugated to NaYF4:Yb3+/Er3+@SiO2-PEG nanoparticles, which were intravenously administered in athymic nude mice with xenotransplanated human prostate carcinoma PC-3. After NIR photodynamic therapy, the tumor subsided and its volume approached to zero.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

TechConnect Briefs 2017 : Biotech, Biomaterials and Biomedical

ISBN

978-0-9988782-0-1

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

114-117

Název nakladatele

TechConnect

Místo vydání

Danville

Místo konání akce

Washington, US

Datum konání akce

14. 5. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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